Development of potential manufacturing routes for substituted thiophenes – Preparation of halogenated 2-thiophenecarboxylic acid derivatives as building blocks for a new family of 2,6-dihaloaryl 1,2,4-triazole insecticides

• John W. Hull Jr.,
• Duane R. Romer,
• David E. Podhorez,
• Mezzie L. Ash and
• Christine H. Brady

Beilstein J. Org. Chem. 2007, 3, No. 23, doi:10.1186/1860-5397-3-23

• ). [22][23] The vapor phase chlorination of nitrogen heterocycles has been reported. [22] The analogous vapor phase chlorination of thiophene 20 was carried out in the present study using a down flow quartz reactor tube heated with an electric furnace to high temperatures, and filled with an inert

An efficient synthesis of tetramic acid derivatives with extended conjugation from L-Ascorbic Acid

• Biswajit K. Singh,
• Surendra S. Bisht and
• Rama P. Tripathi

Beilstein J. Org. Chem. 2006, 2, No. 24, doi:10.1186/1860-5397-2-24

• antibiotics and thus this method offers a new and short route for the synthesis of tetramic acid derivatives of biological significance. 1. Background Tetramic acid derivatives constitute an important class of nitrogen heterocycles with pyrrolidine-2,4-dione moieties and are key structural motifs in many