Volatile organic compounds produced by the phytopathogenic bacterium Xanthomonas campestris pv. vesicatoria 85-10

• Teresa Weise,
• Marco Kai,
• Anja Gummesson,
• Armin Troeger,
• Stephan von Reuß,
• Silvia Piepenborn,
• Francine Kosterka,
• Martin Sklorz,
• Ralf Zimmermann,
• Wittko Francke and
• Birgit Piechulla

Beilstein J. Org. Chem. 2012, 8, 579–596, doi:10.3762/bjoc.8.65

• dahliae, Paecilomyces carneus and Sclerotinia sclerotiorum were strongly inhibited by the rhizobacteria (Serratia spp., Pseudomonas spp., Stenotrophomonas spp.), and only F. solani appeared to be resistant against the bacterial volatiles. Also Muscodor albus volatiles only partially influence the growth

• investigated more comprehensively. In addition, inorganic compounds have to be considered, including hydrogen cyanide (HCN) and ammonia. HCN is produced, e.g., by Pseudomonas spp. [55] and, due to its slightly higher proton affinity than water, it should be detectable down to a concentration lower than 100 ppb

Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum

• Friederike I. Nollmann,
• Andrea Dowling,
• Marcel Kaiser,
• Klaus Deckmann,
• Sabine Grösch,
• Richard ffrench-Constant and
• Helge B. Bode

Beilstein J. Org. Chem. 2012, 8, 528–533, doi:10.3762/bjoc.8.60

• different Gram-positive (Micrococcus luteus, Bacillus subtilis, Staphylococcus aureus) and Gram-negative (Escherichia coli, Pseudomonas aeroginosa) bacteria, as well as yeast (Candida albicans, Saccharomyces cerivisiae). However, consistent with the published data [12], no antibacterial or antifungal

Mutational analysis of a phenazine biosynthetic gene cluster in Streptomyces anulatus 9663

• Orwah Saleh,
• Katrin Flinspach,
• Lucia Westrich,
• Andreas Kulik,
• Bertolt Gust,
• Hans-Peter Fiedler and
• Lutz Heide

Beilstein J. Org. Chem. 2012, 8, 501–513, doi:10.3762/bjoc.8.57

• phenazines are secondary metabolites, produced mainly by different species of the proteobacterium Pseudomonas and of the actinobacterium Streptomyces. While Pseudomonas strains produce phenazine derivatives with relatively simple structures, more complex phenazines are produced by Streptomyces strains [1

• ]. The biosynthesis of phenazine-1-carboxylic acid (PCA) and its derivatives has been studied extensively in Pseudomonas [2][3][4][5]. The biosynthesis of PCA requires a set of seven genes named phzABCDEFG [3][6]. PhzC codes for DAHP (3-deoxy-D-arabinoheptulosonate-7-phosphate) synthase, the first enzyme

• ]. The LysR-like protein PqsR from Pseudomonas sp. M18 is involved in the regulation of phenazine biosynthesis. Inactivation of pqsR resulted in almost complete abolishment of the transcription of the phenazine biosynthesis genes [21]. It may therefore be speculated that ppzY codes for a positive

Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes

• Jan-Christoph Kehr,
• Douglas Gatte Picchi and
• Elke Dittmann

Beilstein J. Org. Chem. 2011, 7, 1622–1635, doi:10.3762/bjoc.7.191

• mechanism of ureido bond formation remains to be elucidated. Recently, ureido bond formation was characterized for the protease inhibitor syringolin A that is produced by Pseudomonas syringiae [35]. The responsible freestanding NRPS module contains a sequence stretch with similarity to acyltransferases

Coupled chemo(enzymatic) reactions in continuous flow

• Ruslan Yuryev,
• Simon Strompen and
• Andreas Liese

Beilstein J. Org. Chem. 2011, 7, 1449–1467, doi:10.3762/bjoc.7.169

• continuous epoxidation of 1,7-octadiene (70) to (R)-7-epoxyoctene (72) by a strain of Pseudomonas oleovorans growing on heptane (71) (Scheme 23) [51]. In a continuous operation, with regard to the aqueous phase, substrates for both growth and biotransformation were supplied in the gas phase from a reservoir

• biofilm membrane reactor (Scheme 24) [52][53]. Cells of Pseudomonas sp. were grown in a biofilm attached to the inner surface of a silicon tube, through which a nutrient solution was constantly pumped. In a specially designed hermetic reaction compartment the tube was partially submerged into liquid 73

• ]. Continuous epoxidation of 1,7-octadiene (70) to (R)-7-epoxyoctene (72) by a strain of Pseudomonas oleovorans in a closed-gas-loop bioreactor (CCGLB). R: Reductase; Fe: Rubredoxin [51]. Oxidation of styrene (73) to (S)-styrene oxide (74) in a continuously operated biofilm tube reactor containing cells of

Synthesis, reactivity and biological activity of 5-alkoxymethyluracil analogues

• Lucie Brulikova and
• Jan Hlavac

Beilstein J. Org. Chem. 2011, 7, 678–698, doi:10.3762/bjoc.7.80

• tested for their antimicrobial activity against standard reference gram-positive and gram-negative bacterial strains such as Enterococcus faecalis CCM 4224, Staphylococcus aureus CCM 3953, Escherichia coli CCM 3954 and Pseudomonas aeruginosa CCM 3955 and against gram-positive and gram-negative bacteria

• obtained from clinical material of patients treated at the University Hospital in Olomouc (methicillin resistant Staphylococcus aureus - MRSA, Staphylococcus haemolyticus, Escherichia coli and Pseudomonas aeruginosa) with resistance to currently used fluoroquinolones. Only the octyl and nonyl derivatives

β-Hydroxy carbocation intermediates in solvolyses of di- and tetra-hydronaphthalene substrates

• Jaya S. Kudavalli and
• Rory A. More O'Ferrall

Beilstein J. Org. Chem. 2010, 6, 1035–1042, doi:10.3762/bjoc.6.118

• -arenedihydrodiols are products of fermentation of aromatic molecules by mutant strains of soil bacteria containing dioxygenase enzymes such as Pseudomonas putida UV4 [1]. A characteristic reaction they undergo is acid-catalysed dehydration to form phenols [2], as illustrated for benzene-1,2-dihydrodiol in Scheme 1

One-pot three-component synthesis of quinoxaline and phenazine ring systems using Fischer carbene complexes

• Priyabrata Roy and
• Binay Krishna Ghorai

Beilstein J. Org. Chem. 2010, 6, No. 52, doi:10.3762/bjoc.6.52

• heterocycles which exhibit a wide range of biological activities. Many phenazine compounds are found in nature and are produced by bacteria such as Pseudomonas spp., Streptomyces spp. and Pantoea agglomerans. These phenazine natural products have been implicated in the virulence and competitive fitness of the

Recent progress on the total synthesis of acetogenins from Annonaceae

• Nianguang Li,
• Zhihao Shi,
• Yuping Tang,
• Jianwei Chen and
• Xiang Li

Beilstein J. Org. Chem. 2008, 4, No. 48, doi:10.3762/bjoc.4.48

One-pot synthesis of novel 1H-pyrimido[4,5-c][1,2]diazepines and pyrazolo[3,4-d]pyrimidines

• Dipak Prajapati,
• Partha P. Baruah,
• Baikuntha J. Gogoi and
• Jagir S. Sandhu

Beilstein J. Org. Chem. 2006, 2, No. 5, doi:10.1186/1860-5397-2-5

• -c]pyridazine-5,7-dione), inhibits the growth of Pseudomonas 568 and also binds to herring sperm DNA.[7] However, until the emergence of HEPT[8] as a potent and selective inhibitor of HIV-1, no attention was given to the synthetic manipulation at the 6-position of uracils. Also the synthetic

New modification of the Perkow reaction: halocarboxylate anions as leaving groups in 3-acyloxyquinoline- 2,4(1H,3H)-dione compounds

• Oldřich Paleta,
• Karel Pomeisl,
• Stanislav Kafka,
• Antonín Klásek and
• Vladislav Kubelka

Beilstein J. Org. Chem. 2005, 1, No. 17, doi:10.1186/1860-5397-1-17

• fluorinated but-2-enolide rings. The 3-alkyl-3-hydroxyquinoline-2,4(1H,3H)-dione metabolites of Pseudomonas species exhibit antibiotic or lipoxygenase inhibitor activity[1] that may be modified by the introduction of an annulated pharmacophoric but-2-enolide ring. [2] The annulation was successfully carried