The use of chiral lithium amides in the desymmetrisation of N-trialkylsilyl dimethyl sulfoximines

• Matthew J. McGrath and
• Carsten Bolm

Beilstein J. Org. Chem. 2007, 3, No. 33, doi:10.1186/1860-5397-3-33

• enantioenriched S-chiral sulfoximines but both methods lack generality due to the limited availability of the appropriate chiral sulfoxides and the limited scope for cleavage of the chiral auxiliary in the latter process. [6][7][8][9][10][11][12][13][14][15] Selective substitution of one of the enantiotopic

Asymmetric aza-Diels- Alder reaction of Danishefsky's diene with imines in a chiral reaction medium

• Bruce Pégot,
• Olivier Nguyen Van Buu,
• Didier Gori and
• Giang Vo-Thanh

Beilstein J. Org. Chem. 2006, 2, No. 18, doi:10.1186/1860-5397-2-18

• )-(-)-methylbenzylamine chiral auxiliary. However, all reactions had to be performed in an organic solvent under an inert atmosphere and required stoichiometric loadings of Lewis acid promoter, the use of which is not recommended under 'green chemistry' conditions. Having established the high efficiency of chiral ILs is

Stereoselective α-fluoroamide and α-fluoro- γ-lactone synthesis by an asymmetric zwitterionic aza-Claisen rearrangement

• Kenny Tenza,
• Julian S. Northen,
• David O'Hagan and
• Alexandra M. Z. Slawin

Beilstein J. Org. Chem. 2005, 1, No. 13, doi:10.1186/1860-5397-1-13

• rearrangement (S)-2(methoxymethyl)pyrrolidine 22 was then explored as the chiral auxiliary.[25] This auxiliary was selected to include a co-ordinating oxygen in place of the bulky diphenylmethane group in 14 to compare steric versus co-ordination effects. Allylation then gave 23 as the required aza-Claisen

Methods for the synthesis of polyhydroxylated piperidines by diastereoselective dihydroxylation: Exploitation in the two-directional synthesis of aza-C-linked disaccharide derivatives

• Andrew Kennedy,
• Adam Nelson and
• Alexis Perry

Beilstein J. Org. Chem. 2005, 1, No. 2, doi:10.1186/1860-5397-1-2

• chiral auxiliary. The source of the asymmetry means that the approach would be amenable to the synthesis of the enantiomeric aza-C-linked disaccharide derivatives. A key feature of the approach was the potential to switch between one- and two-directional synthetic steps, allowing the selective