Synthesis of unsymmetrically substituted biaryls via sequential lithiation of dibromobiaryls using integrated microflow systems

• Aiichiro Nagaki,
• Naofumi Takabayashi,
• Yutaka Tomida and
• Jun-ichi Yoshida

Beilstein J. Org. Chem. 2009, 5, No. 16, doi:10.3762/bjoc.5.16

• because of the frequent occurrence of such structures in natural products, pharmaceuticals, agrochemicals, and functional organic materials [1]. Transition metal-catalyzed cross-coupling of arylmetal compounds with aryl halides or triflates serves as a useful method for preparation of such unsymmetrical