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Search for "saponification" in Full Text gives 104 result(s) in Beilstein Journal of Organic Chemistry.

Recent progress on the total synthesis of acetogenins from Annonaceae

  • Nianguang Li,
  • Zhihao Shi,
  • Yuping Tang,
  • Jianwei Chen and
  • Xiang Li

Beilstein J. Org. Chem. 2008, 4, No. 48, doi:10.3762/bjoc.4.48

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  • macrocyclization. Hydrogenation of the olefins followed by saponification of macrolactones 106 and 107 with NaOMe and subsequent MOM protection gave the common intermediate 108 with identical physical data independent of the route used. The lithium enolate formed from 108 with LDA was treated with 109 and the
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Published 05 Dec 2008

Diastereoselective and enantioselective reduction of tetralin- 1,4-dione

  • E. Peter Kündig and
  • Alvaro Enriquez-Garcia

Beilstein J. Org. Chem. 2008, 4, No. 37, doi:10.3762/bjoc.4.37

Graphical Abstract
  • % yield). Saponification and fractional recrystallization from MeOH / Et2O then afforded pure 6 and 7 though isolated yields were not reported [9]. The meso-diol 6 has been used as substrate in enantioselective oxidation [10] and in asymmetric acylation [9][11]. We conclude that while conditions for an
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Published 22 Oct 2008

Sordarin, an antifungal agent with a unique mode of action

  • Huan Liang

Beilstein J. Org. Chem. 2008, 4, No. 31, doi:10.3762/bjoc.4.31

Graphical Abstract
  • into 75 by protection of the OH group with TBDPSCl and saponification of the benzoate ester (LiOH). Lewis acid-induced glycosylation [46] of 75 with trichloroacetimidate 76 gave 77. The latter was then subjected to TBAF deprotection, PCC oxidation, and Pd/C hydrogenation, to afford analog 78. Isopentyl
  • ether 80 was prepared via ethylene glycol protection, saponification, alkylation by prenyl bromide, hydrogenation and acetonide cleavage. Two other analogs were assembled from 70 by LiOH hydrolysis of the benzoate ester and Pd/C hydrogenolysis of the benzyl one. While biological tests indicated that
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Published 05 Sep 2008

Stereoselective α-fluoroamide and α-fluoro- γ-lactone synthesis by an asymmetric zwitterionic aza-Claisen rearrangement

  • Kenny Tenza,
  • Julian S. Northen,
  • David O'Hagan and
  • Alexandra M. Z. Slawin

Beilstein J. Org. Chem. 2005, 1, No. 13, doi:10.1186/1860-5397-1-13

Graphical Abstract
  • -fluoropropionyl chloride 9 were explored but the method of choice involved nucleophilic fluorination of the mesylate 7 with KF to give ethyl 2-fluoropropionate 8 (Scheme 2).[19] Saponification and then treatment with phthaloyl dichloride gave 9 after distillation. 2-Fluorophenylacetyl chloride was prepared from
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Published 17 Oct 2005
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