Towards practical biocatalytic Baeyer- Villiger reactions: applying a thermostable enzyme in the gram- scale synthesis of optically- active lactones in a two-liquid- phase system

• Frank Schulz,
• François Leca,
• Frank Hollmann and
• Manfred T. Reetz

Beilstein J. Org. Chem. 2005, 1, No. 10, doi:10.1186/1860-5397-1-10

• of tolerance towards organic solvents. We speculated that thermostable alcohol dehydrogenases may meet these demands and decided to use the secondary alcohol dehydrogenase (2°ADH) from Thermoanaerobacter ethanolicus.[51][52][53][54][55][56] This 2°ADH oxidizes secondary alcohols like isopropanol to