Asymmetric reactions in continuous flow

• Xiao Yin Mak,
• Paola Laurino and
• Peter H. Seeberger

Beilstein J. Org. Chem. 2009, 5, No. 19, doi:10.3762/bjoc.5.19

• unmodified silica lowered the activity of the catalyst system, presumably via adsorption of some of the Ru(II) catalyst. Under optimal flow conditions, the transfer hydrogenation of acetophenone in isopropanol (using a flow-reactor consisting of a column packed with a slurry of the immobilized catalyst