Trifluoromethyl ethers – synthesis and properties of an unusual substituent

• Frédéric R. Leroux,
• Baptiste Manteau,
• Jean-Pierre Vors and
• Sergiy Pazenok

Beilstein J. Org. Chem. 2008, 4, No. 13, doi:10.3762/bjoc.4.13

• biggest group of fluorinated pesticides are the compounds containing a trifluoromethyl group (mainly at aromatic rings), followed by aromatic compounds containing an isolated fluorine atom (one and more). However, according to the 12th and 13th edition of the pesticide manual only five pesticides

• groups. Nevertheless, the occurrence of OCF3-substituted organics, the majority of which are aromatic compounds, has significantly increased in the recent years [12]. In the 1950s and 1960s the successful development of α-fluorinated ethers as volatile, non-toxic, non-explosive and fast-acting inhalation