Total synthesis of the indolizidine alkaloid tashiromine

• Stephen P. Marsden and
• Alison D. McElhinney

Beilstein J. Org. Chem. 2008, 4, No. 8, doi:10.1186/1860-5397-4-8

• attempted cross-metathesis of (hydroxy)allylsilane 12. Supporting Information Supporting Information File 36: Supporting Information. Full experimental details and compound characterisation data for all new compounds described. Acknowledgements We thank the EPSRC for a studentship (ADM) and Pfizer and

Facile synthesis of two diastereomeric indolizidines corresponding to the postulated structure of alkaloid 5,9E- 259B from a Bufonid toad (Melanophryniscus)

• Angela Nelson,
• H. Martin Garraffo,
• Thomas F. Spande,
• John W. Daly and
• Paul J. Stevenson

Beilstein J. Org. Chem. 2008, 4, No. 6, doi:10.1186/1860-5397-4-6

• periodinane, 77%. (b) Ph3P+CH2I I-, NaN(SiMe3)2 51%. (c) TMS acetylene, CuI, Pd(Ph3P)3, Et3N then K2CO3 MeOH, 69%. Supporting Information Supporting Information File 28: Experimental. Details of experimental procedures and data for characterisation of new compounds. Acknowledgements We would like to thank

Analogues of amphibian alkaloids: total synthesis of (5R,8S,8aS)-(−)-8-methyl- 5-pentyloctahydroindolizine (8-epi-indolizidine 209B) and [(1S,4R,9aS)-(−)-4-pentyloctahydro- 2H-quinolizin- 1-yl]methanol

• Joseph P. Michael,
• Claudia Accone,
• Charles B. de Koning and
• Christiaan W. van der Westhuyzen

Beilstein J. Org. Chem. 2008, 4, No. 5, doi:10.1186/1860-5397-4-5

• experimental procedures and full characterisation data for all new compounds prepared during the synthesis of the two title compounds. Acknowledgements This work was supported by grants from the National Research Foundation, Pretoria (grant number 2053652) and the University of the Witwatersrand. We are

The use of chiral lithium amides in the desymmetrisation of N-trialkylsilyl dimethyl sulfoximines

• Matthew J. McGrath and
• Carsten Bolm

Beilstein J. Org. Chem. 2007, 3, No. 33, doi:10.1186/1860-5397-3-33

• in the desymmetrisation of N-trialkylsilyl dimethyl sulfoximines. Detailed experimental procedures and characterisation data. Supporting Information File 36: The use of chiral lithium amides in the desymmetrisation of N-trialkylsilyl dimethyl sulfoximines. 1H and 13C NMR Spectra. Acknowledgements

The use of silicon- based tethers for the Pauson- Khand reaction

• Adrian P. Dobbs,
• Ian J. Miller and
• Saša Martinović

Beilstein J. Org. Chem. 2007, 3, No. 21, doi:10.1186/1860-5397-3-21

• Pauson-Khand precursors. Failed Pauson-Khand reaction of a silicon-tethered substrate. Diiso propylsilyl ether formation and subsequent Pauson-Khand reactions Supporting Information Supporting Information File 32: Representative Experimental Procedures and Characterisation Data for Si-tethered P-K

Pd-catalysed [3 + 3] annelations in the stereoselective synthesis of indolizidines

• Olivier Y. Provoost,
• Andrew J. Hazelwood and
• Joseph P. A. Harrity

Beilstein J. Org. Chem. 2007, 3, No. 8, doi:10.1186/1860-5397-3-8

• Supporting Information Supporting Information File 86: Supporting information. Experimental procedures and compound characterisation. Acknowledgements We thank the EPSRC and GSK for studentship funding.

Tether- directed synthesis of highly substituted oxasilacycles via an intramolecular allylation employing allylsilanes

• Peter J. Jervis and
• Liam R. Cox

Beilstein J. Org. Chem. 2007, 3, No. 6, doi:10.1186/1860-5397-3-6

• allylation results. Supporting Information Supporting Information File 75: Experimental details and characterisation data. Supporting Information File 76: 1H-NMR and 13C-NMR Spectra for the following compounds: 5b, 6b, 7b, syn-8b, anti-8b, syn-11b, anti-11b, syn-4b, anti-4b, syn-9a, anti-9a, syn-12a, anti

The vicinal difluoro motif: The synthesis and conformation of erythro- and threo- diastereoisomers of 1,2-difluorodiphenylethanes, 2,3-difluorosuccinic acids and their derivatives

• David O'Hagan,
• Henry S. Rzepa,
• Martin Schüler and
• Alexandra M. Z. Slawin

Beilstein J. Org. Chem. 2006, 2, No. 19, doi:10.1186/1860-5397-2-19

• medicinal chemistry research to materials science. Experimental details for the preparation and characterisation of compounds 13, 14, 15, 19, 21, 22 and 24 are given in Supporting Information File 1. Crystal structure of erythro-13. X-ray structure of threo-13. Expanded regions of the second order AA'XX

• - and threo- 20. The synthesis of stereoisomers of erythro- and threo- 22. These isomers could be separated by chromatography. Supporting Information Supporting Information File 59: Experimental and characterisation details of synthesised compounds. Supporting Information File 60: Calculated

Multiple hydride reduction pathways in isoflavonoids

• Auli K. Salakka,
• Tuija H. Jokela and
• Kristiina Wähälä

Beilstein J. Org. Chem. 2006, 2, No. 16, doi:10.1186/1860-5397-2-16

• File 50: Experimental details and characterisation data. Acknowledgements This work was partially funded within the Finnish Academy project no 178253. Funding to AKS and THJ from the Foundation of Emil Aaltonen and from the Jenny and Antti Wihuri Foundation to KW are gratefully acknowledged. We thank

The oxanorbornene approach to 3-hydroxy, 3,4-dihydroxy and 3,4,5-trihydroxy derivatives of 2-aminocyclohexanecarboxylic acid

• Ishmael B. Masesane,
• Andrei S. Batsanov,
• Judith A. K. Howard,
• Raju Mondal and
• Patrick G. Steel

Beilstein J. Org. Chem. 2006, 2, No. 9, doi:10.1186/1860-5397-2-9

• aqueous perchloric acid led to a single trans diol, albeit accompanied by the loss of the Boc protecting group. Characterisation of the peracetylated derivative 27 suggested that nucleophilic attack had occurred at the allylic position. Support for this was confirmed by ring opening with ZnCl2 to afford