Beilstein J. Org. Chem.2006,2, No. 26, doi:10.1186/1860-5397-2-26
to the freeradical redox-processes, involving triptycene-quinones and reactive oxygen species [2]. Better understanding of the transannular influence of a substituent on the redox-potentials of bicyclo[2.2.2]octane-derived quinones will help in the design of new compounds with controlled biological
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Graphical Abstract
Figure 1:
Bicyclic quinones explored for the transannular interaction.
Beilstein J. Org. Chem.2006,2, No. 22, doi:10.1186/1860-5397-2-22
solvent. The sulfate ester remains in the aqueous phase. Hydrolysis of the sulfate ester in aqueous acid produces the (usually) organic-soluble dihydric phenol. Reactions are usually run at room temperature or below to reduce the incursion of freeradical reactions. The rates are rather slow with typical