From discovery to production: Scale- out of continuous flow meso reactors

• Peter Styring and
• Ana I. R. Parracho

Beilstein J. Org. Chem. 2009, 5, No. 29, doi:10.3762/bjoc.5.29

• product so the possibility arises that the catalyst takes an alternative pathway (route B) once the catalyst initiation has occurred. As the cross-coupled product is observed as the highest yielding product, it was proposed that the rate constant for route A is smaller than for route B. The proposed

Radical cascades using enantioenriched 7-azabenzonorbornenes and their applications in synthesis

• David M. Hodgson and
• Leonard H. Winning

Beilstein J. Org. Chem. 2008, 4, No. 38, doi:10.3762/bjoc.4.38

• under conditions [refluxing toluene, thermal initiation by AIBN] similar to those we had previously reported for the tandem deoxygenation–rearrangement–reduction of 7-azabenzonorbornenyl xanthates (e.g. 5 to 8, Scheme 2), although the work in our laboratory had employed a syringe pump in order to

Stereoselective synthesis of (2S,3S,4Z)-4-fluoro- 1,3-dihydroxy- 2-(octadecanoylamino)octadec- 4-ene, [(Z)-4-fluoroceramide], and its phase behavior at the air/water interface

• Gergana S. Nikolova and
• Günter Haufe

Beilstein J. Org. Chem. 2008, 4, No. 12, doi:10.3762/bjoc.4.12

• [12][13]. The specific initiation of apoptosis by suitable derivatives of these signal molecules is discussed as a new method for treatment of numerous diseases [1][14][15], and of cancer in particular [16][17][18]. A few years ago Herdewijn et al. showed that fluorinated ceramide and dihydroceramide

Part 3. Triethylborane- air: a suitable initiator for intermolecular radical additions of S-2-oxoalkyl- thionocarbonates (S-xanthates) to olefins

• Jean Boivin and
• Van Tai Nguyen

Beilstein J. Org. Chem. 2007, 3, No. 47, doi:10.1186/1860-5397-3-47

• viewpoint, the results reported herein may be rationalised as follows (Scheme 2). The initiation of the process is governed by interaction of dioxygen with Et3B to give Et•. This reaction occurs within a wide range of temperatures. The reaction of ethyl radical with the highly radicophilic species A leads