Synthesis of novel (1-alkanoyloxy- 4-alkanoylaminobutylidene)-1,1-bisphosphonic acid derivatives

• Petri A. Turhanen and
• Jouko J. Vepsäläinen

Beilstein J. Org. Chem. 2006, 2, No. 2, doi:10.1186/1860-5397-2-2

• have also recently described the method for the preparation of (1-alkoxycarbonyloxyethylidene)-1,1-bisphosphonic acid derivatives [20] and novel fatty acid derivatives of etidronate [21] which may represent prodrugs of etidronate. In the case of etidronic acid, we have shown that simple phosphonate