Synthetic incorporation of Nile Blue into DNA using 2′-deoxyriboside substitutes: Representative comparison of (R)- and (S)-aminopropanediol as an acyclic linker

• Daniel Lachmann,
• Sina Berndl,
• Otto S. Wolfbeis and
• Hans-Achim Wagenknecht

Beilstein J. Org. Chem. 2010, 6, No. 13, doi:10.3762/bjoc.6.13

• the 2′-deoxyriboside between the phosphodiester bridges. Similar propanediol derivatives have been used extensively as alternative and simplified phosphodiester linkers in the 1990s [19][20][21][22][23], and have been further explored for glycol nucleic acid (GNA) [24][25][26] twisted intercalating

• experimental result can be imaged by geometrically optimized DNA models. Our result is remarkable regarding opposite results with the L-/D-threoninol linkers [37][38][39][40] that revealed strong differences in stacking and also in function of attached chromophores depending on the chirality of the linker. We

Synthesis and binding studies of two new macrocyclic receptors for the stereoselective recognition of dipeptides

• Ana Maria Castilla,
• M. Morgan Conn and
• Pablo Ballester

Beilstein J. Org. Chem. 2010, 6, No. 5, doi:10.3762/bjoc.6.5

• synthetic receptors for peptides [11][12][13][14][15][16]. However, we believe that our design includes some novelties. To reduce the conformational flexibility and confer a certain degree of preorganization to this type of receptor, the use of one or two linkers connecting the two peptide strands is

• introduction of two linkers connecting the two peptide strands affording, a macrocyclic structure. In doing so, we expect that the molecular recognition properties of the designed receptor will also benefit from the macrocyclic effect [17][18][19][20]. Simple molecular modeling studies [21] revealed that a

• macrocycle, also allows for the possibility of binding short amino acid sequences not necessarily located on the edges of larger peptides. Other considerations, apart from preventing intramolecular hydrogen bond formation, related to the use of bis(alanyl)benzophenone rigid linkers include: a) to avoid

Versatile supramolecular reactivity of zinc-tetra(4-pyridyl)porphyrin in crystalline solids: Polymeric grids with zinc dichloride and hydrogen-bonded networks with mellitic acid

• Sophia Lipstman and
• Israel Goldberg

Beilstein J. Org. Chem. 2009, 5, No. 77, doi:10.3762/bjoc.5.77

• chemistry. In this work, it was found to be reactive in the assembly of both (a) a 2D polymeric array by a unique combination of self-coordination and coordination through external zinc dichloride linkers and (b) an extended heteromolecular hydrogen-bonded network with mellitic acid sustained by multiple

• , in which the porphyrin units are inter-coordinated via exocyclic metal ion linkers (e.g., tetrahedral CuI), has also been observed [5]. The latter mode of coordination polymerization, in which the peripheral pyridyl sites of different TPyP/MTPyP moieties can be readily bridged by various metal ion

• assemblies of varying dimensionality with the aid of exocyclic metal ion linkers capable of coordinating simultaneously to several neighboring ZnTPyP units [5][6][7][8][9][10][11]. The ZnTPyP can adopt in the above constructs either five-coordinate or six-coordinate geometries, which affects the architecture

Silica- bound benzoyl chloride mediated the solid- phase synthesis of 4H-3,1-benzoxazin- 4-ones

• Kurosh Rad-Moghadam and
• Somayeh Rouhi

Beilstein J. Org. Chem. 2009, 5, No. 13, doi:10.3762/bjoc.5.13

• . Apparently, owing to porous nature of silica chloride, a significant fraction of the silyl chloride linkers remains unreacted even in treatment with excess 4-hydroxybenzoic acid during the loading process. On the other hand, and for the same reason, many of the graft sites may be unavailable or more hindered

Convenient methods for preparing π-conjugated linkers as building blocks for modular chemistry

• Jiří Kulhánek,
• Filip Bureš and
• Miroslav Ludwig

Beilstein J. Org. Chem. 2009, 5, No. 11, doi:10.3762/bjoc.5.11

• π-conjugated linkers are described. Either unsubstituted or 4-donor substituted π-linkers bearing a styryl, biphenyl, phenylethenylphenyl, and phenylethynylphenyl π-conjugated backbone are functionalized with boronic pinacol esters as well as with terminal acetylene moieties allowing their further

• moieties is usually accomplished by cross-coupling reactions, in particular by the Suzuki–Miyaura [26][27] or the Sonogashira [28] reactions. Consequently, the availability of the suitably substituted π-conjugated linkers of various lengths bearing boronic ester functionality or terminal acetylene is

• crucial for such a synthetic approach. Hence, we report here a convenient synthesis as well as characterization of either unsubstituted (R = H) or donor substituted (R = NMe2, OMe) π-conjugated linkers designed for the Suzuki–Miyaura and Sonogashira cross-couplings with a systematically varied and