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Search for "nitriles" in Full Text gives 180 result(s) in Beilstein Journal of Organic Chemistry.

Synthesis of methylenebisamides using CC- or DCMT- activated DMSO

  • Qiang Wang,
  • Lili Sun,
  • Yu Jiang and
  • Chunbao Li

Beilstein J. Org. Chem. 2008, 4, No. 51, doi:10.3762/bjoc.4.51

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  • ], hexamethylenetetramine [21] or activated DMSO [6], or by the reaction of nitriles with formaldehyde [22] or activated sulfoxides [23]. However, each method has certain limitations with regards to scope and reaction conditions, for example, longer reaction time [20], lower yield [6], purification problems [21][23] and
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Published 15 Dec 2008

The role of an aromatic group in remote chiral induction during conjugate addition of α-sulfonylallylic carbanions to ethyl crotonate

  • Shlomo Levinger,
  • Ranjeet Nair and
  • Alfred Hassner

Beilstein J. Org. Chem. 2008, 4, No. 32, doi:10.3762/bjoc.4.32

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  • acetophenones. Preparation of [(9-anthryl)alkyl]- and (mesitylalkyl)amines 6h and 6j from nitriles via imines 8. Preparation of α-sulfonylallylic donor precursors 1 according to Scheme 2. Remote chiral induction in the conjugate addition of lithiated α-sulfonylallyl anions of 1 to ethyl crotonate (2
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Published 23 Sep 2008

Efficient 1,4-addition of α-substituted fluoro(phenylsulfonyl)methane derivatives to α,β-unsaturated compounds

  • G. K. Surya Prakash,
  • Xiaoming Zhao,
  • Sujith Chacko,
  • Fang Wang,
  • Habiba Vaghoo and
  • George A. Olah

Beilstein J. Org. Chem. 2008, 4, No. 17, doi:10.3762/bjoc.4.17

Graphical Abstract
  • nucleophile to a variety of α,β-unsaturated compounds has been achieved under mild conditions using either phosphines or potassium carbonate at room temperature. α-Substituted fluoro(phenylsulfonyl)methane easily undergoes Michael addition to α,β-unsaturated ketones, esters, nitriles, sulfones, as well as
  • /DMF system was found to be very efficient both in terms of conversions as well as reaction times. The reactions were carried out at room temperature and the completion observed within 2 h. The reaction was found to be versatile for various α,β-unsaturated compounds such as ketones, esters, nitriles
  • and sulfones (Table 3). In case of α,β-unsaturated aldehydes the reaction was found to be not clean and too many fluorine peaks appeared in the 19F NMR even when the reaction was carried out at low temperatures. On the other hand, α,β-unsaturated nitriles underwent a second Michael addition of the
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Published 21 May 2008

Allylsilanes in the synthesis of three to seven membered rings: the silylcuprate strategy

  • Asunción Barbero,
  • Francisco J. Pulido and
  • M. Carmen Sañudo

Beilstein J. Org. Chem. 2007, 3, No. 16, doi:10.1186/1860-5397-3-16

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  • -vinylcuprate species toward electrophiles increases their synthetic potential (Scheme 1). [7][8] A large number of electrophiles (alkyl and allyl halides, epoxides, ketones, α,β-unsaturated oxo compounds and acid chlorides, unsaturated nitriles and imines) have been successfully used in this reaction, leading
  • key step is the syn addition of the tin cuprate to the acetylene, which controls the cis stereochemistry required for cyclization. [23] Seven Membered Carbocycles The use of nitriles and imines as electrophiles in the silylcupration of allene provides new alternatives for carbocyclization. Recently
  • , we showed that α,β-unsaturated nitriles undergo a double addition process when treated with the cuprate species resulting from addition of 1 to allene, giving ketones 44 containing both an allylsilane group and a vinylsilane moiety (Scheme 10). [24] Equilibration between species 2 and 45 as the
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Published 22 May 2007

Cobalt(II) chloride catalyzed one-pot synthesis of α-aminonitriles

  • Surya K. De

Beilstein J. Org. Chem. 2005, 1, No. 8, doi:10.1186/1860-5397-1-8

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  • (II) chloride- catalyzed synthesis of α-amino nitriles with potassium cyanide Supporting Information Supporting Information File 6: Experimental details.
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Published 07 Oct 2005
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