Study of thioglycosylation in ionic liquids

• Jianguo Zhang and
• Arthur Ragauskas

Beilstein J. Org. Chem. 2006, 2, No. 12, doi:10.1186/1860-5397-2-12

• ionic liquids for the synthesis of alkyl glycoside and disaccharides via coupling of thioalkyl glycosyl donors with glycal acceptors. Alkyl glycosides and oligosaccharides are important intermediates and products in the synthesis of biologically active natural compounds and mimics. For example, tetra-O

• reactivity in the synthesis of oligosaccharides. Donor activation is frequently accomplished by using heavy metal salts or more directly, and efficiently, by thiophilic reagents such as methyltriflate, NBS, and DMTST.[15][16] The stereoselectivity of the glycosylation reaction is greatly influenced by the