Synthesis of deep- cavity fluorous calix[4]arenes as molecular recognition scaffolds

• Maksim Osipov,
• Qianli Chu,
• Steven J. Geib,
• Dennis P. Curran and
• Stephen G. Weber

Beilstein J. Org. Chem. 2008, 4, No. 36, doi:10.3762/bjoc.4.36

• have included nanowires [3], self organized nanostructures [4] chiral supramolecular assemblies [5], as well as sensors for cations [6][7], anions [8] and neutral organic molecules [9]. The versatility of the calixarene scaffold is a result of its preorganized cavity [10], which consists of four

• recyclable reagents [18] to the total synthesis of natural products [19]. Fluorous compounds are the basis for highly selective ion sensors that show promise by virtue of their low level of biofouling [20]. Recently, it was shown that simple fluorous compounds act as molecular receptors for selective

• are locked in the cone conformation have been synthesized. These molecules are soluble in several fluorous solvents, and show promise as fluorescent sensors. Introducing the hydroxyl functionality onto these molecules provides a scaffold with a deep cavity and hydrogen bonding functional groups for

Beilstein Journal of Organic Chemistry

• Jonathan Clayden

Beilstein J. Org. Chem. 2005, 1, No. 1, doi:10.1186/1860-5397-1-1

• : para-biologies built, just like the original kind, out of organic chemistry. The synthesis of molecular motors, or sensors, of springs and levers makes possible this new molecular engineering at the nanometre scale for eventual uses which only the future will tell. Expanding scientific horizons are