Beilstein J. Org. Chem.2024,20, 578–588, doi:10.3762/bjoc.20.50
mutagenesis of key enzymes, including terpene cyclases and α-ketoglutarate (αKG)-dependentdioxygenases, that contribute to the structural diversity. Notable progress in genome sequencing has led to the discovery of many novel genes encoding these enzymes, while continued efforts in X-ray crystallographic
for the design of biosynthetic machineries to produce a variety of bioactive meroterpenoids.
Keywords: αKG-dependentdioxygenases; enzyme engineering; fungal meroterpenoids; synthetic biology; terpene cyclases; Introduction
Meroterpenoids are complex natural products with intricate skeletal
of acyl-CoA: cholesterol acyltransferase [4]. In this mini-review, we focus on the fungal meroterpenoids biosynthesis, especially terpenonid cyclizations and post-cyclization modifications, which mostly contribute to the skeletal diversity. Several terpenoid cyclases and αKG-dependentdioxygenases
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Graphical Abstract
Figure 1:
Examples of bioactive fungal meroterpenoids.