Menadione: a platform and a target to valuable compounds synthesis

• Acácio S. de Souza,
• Ruan Carlos B. Ribeiro,
• Dora C. S. Costa,
• Fernanda P. Pauli,
• David R. Pinho,
• Matheus G. de Moraes,
• Fernando de C. da Silva,
• Luana da S. M. Forezi and
• Vitor F. Ferreira

Beilstein J. Org. Chem. 2022, 18, 381–419, doi:10.3762/bjoc.18.43

• studies developed by Naturale’s group, α-, β-, and γ-amino acids of linear and branched chains were used, as well as different amine protection groups (Table 5). The results revealed that the functionalization of naphthoquinones by a radical addition of decarboxylated α-, β- and γ-N-protected amino acids

Vinylphosphonium and 2-aminovinylphosphonium salts – preparation and applications in organic synthesis

• Anna Kuźnik,
• Roman Mazurkiewicz and
• Beata Fryczkowska

Beilstein J. Org. Chem. 2017, 13, 2710–2738, doi:10.3762/bjoc.13.269

• allylamine structure exists in numerous natural products [60]. Moreover, allylamines are widely used in the synthesis of compounds such as β-aminohydroxylamines, β- and γ-amino acids, pseudopeptides, spermidine derivatives or five- and six-membered heterocyclic systems [56]. 2.3.2. In situ generation of α,β

Investigation of the network of preferred interactions in an artificial coiled-coil association using the peptide array technique

• Raheleh Rezaei Araghi,
• Carsten C. Mahrenholz,
• Rudolf Volkmer and
• Beate Koksch

Beilstein J. Org. Chem. 2012, 8, 640–649, doi:10.3762/bjoc.8.71

• 10.3762/bjoc.8.71 Abstract We screened a randomized library and identified natural peptides that bound selectively to a chimeric peptide containing α-, β- and γ-amino acids. The SPOT arrays provide a means for the systematic study of the possible interaction space accessible to the αβγ-chimera. The

• denaturation. Keywords: β- and γ-amino acids; coiled coil; foldamer; screening libraries; SPOT technique; Introduction Coiled-coil domains, which consist of two or more α-helices, are the most common representatives of α-helix-mediated protein–protein interactions, which regulate many important biological

• -mediated interactions to achieve high specificity levels, a pioneering approach is to design helical foldameric sequences containing β- and γ-amino acids. Foldamers are shown to form, successfully, a variety of conformations at secondary, tertiary, and quaternary structure levels [8][9][10]. In spite of