Rh(III)-catalyzed chelation-assisted C–H activation/annulation of 2-arylimidazolines with cyclic diazo-1,3-dicarbonyl compounds: a novel approach to tetracyclic annulated derivatives of 2,3-dihydroimidazo[2,1-a]isoquinoline

• Ivan Lyutin,
• Grigory Kantin,
• Olga Bakulina and
• Dmitry Dar'in

Beilstein J. Org. Chem. 2026, 22, 997–1003, doi:10.3762/bjoc.22.78

• Ivan Lyutin Grigory Kantin Olga Bakulina Dmitry Dar'in Institute of Chemistry, Saint Petersburg State University, 26 Universitetskyi prospekt, Peterhof 198504, Russian Federation 10.3762/bjoc.22.78 Abstract 2-Arylimidazolines were annulated with cyclic diazo-1,3-dicarbonyl compounds under Rh(III

• -heterocycle. Keywords: annulation; 2-arylimidazolines; catalysis; С–H activation; diazodiketones; 2,3-dihydroimidazo[2,1-a]isoquinolines; dimedone; tetraheterocycles; Introduction The advancement of organic synthesis techniques, especially methods for creating nitrogen-containing heterocycles, is essential

• obtaining structurally related 5,6-disubstituted 2,3-dihydroimidazo[2,1-a]isoquinolines 4 (Figure 1c) fused with an additional ring via a Rh(III)-catalyzed chelation-assisted C–H activation/annulation with diazo compounds. 2-Arylimidazolines 2 and various substituted cyclic 1,3-dicarbonyl diazo compounds 3