Synthesis of disulfides and 3-sulfenylchromones from sodium sulfinates catalyzed by TBAI

• Zhenlei Zhang,
• Ying Wang,
• Xingxing Pan,
• Manqi Zhang,
• Wei Zhao,
• Meng Li and
• Hao Zhang

Beilstein J. Org. Chem. 2025, 21, 253–261, doi:10.3762/bjoc.21.17

• -derived Functional Oligosaccharides Engineering Technology Research Center of Anhui Province, Fuyang Normal University, Fuyang, Anhui, 236037, P. R. China 10.3762/bjoc.21.17 Abstract A new synthetic method for disulfides and 3-sulfenylchromones is reported. This innovative approach is based on the

• tetrabutylammonium iodide (TBAI)/H2SO4 reduction system using sodium sulfinate as key component, thus eliminating the need for thiols and redox reagents commonly used in traditional methods. Various disulfides and 3-sulfenylchromones were obtained in moderate to excellent yields through this methodology. Mechanistic

• studies indicate that thiosulfonates play an important role in the reaction process. Keywords: disulfides; sodium sulfinates; 3-sulfenylchromones; TBAI; thiosulfonates; Introduction Organosulfur compounds containing S–S bonds, often referred to as disulfides, are among the most valuable functional

Transition-metal-free synthesis of 3-sulfenylated chromones via KIO₃-catalyzed radical C(sp²)–H sulfenylation

• Yanhui Guo,
• Shanshan Zhong,
• Li Wei and
• Jie-Ping Wan

Beilstein J. Org. Chem. 2017, 13, 2017–2022, doi:10.3762/bjoc.13.199

• , free of any strong oxidants and neutral reaction conditions. Methods on the synthesis of 3-sulfenylchromones. Scope of the 3-sulfenylated chromone synthesis. General conditions: 1 (0.3 mmol), 2 (0.36 mmol), KIO3 (0.15 mmol) in 2 mL DMF, stirred at 130 °C for 24 h; yield of isolated product based on 1