Natural resorcylic lactones derived from alternariol

• Joachim Podlech

Beilstein J. Org. Chem. 2024, 20, 2171–2207, doi:10.3762/bjoc.20.187

• , respectively) [234], against various strains of Paracoccidioides brasiliensis (MIC: 1.9–31.2 µg/mL), against Schizosaccharomyces pombe (MIC: 62.5 µg/mL) [226], and Bacillus subtilis (IC50: 39 µM) [210]. It was antifungal against Botrytis cinereal (inhibitory efficacy of 56.7% at 200 μg/mL) [235], Aspergillus

• fumigatus, A. niger, and Candida albicans (zones of inhibition: 16, 15, 12 mm, respectively, at 200 µg/disc) [229], and against Alternaria alternata (MIC: 1 µg/mL) [236]. It irreversibly inactivated Escherichia coli biotin protein ligase opening a potential application as antimicrobial or biocide [237]. It

Structural basis for endoperoxide-forming oxygenases

• Takahiro Mori and
• Ikuro Abe

Beilstein J. Org. Chem. 2022, 18, 707–721, doi:10.3762/bjoc.18.71

• (FtmOx1) from Aspergillus fumigatus is the first identified nonheme iron and 2-oxoglutarate (Fe/2OG)-dependent endoperoxidase that catalyzes the formation of an endoperoxide in the biosynthesis of verruculogen [26]. Fe/2OG oxygenases utilize Fe(II) as a cofactor and 2OG and O2 as co-substrates (Scheme 3

Cholyl 1,3,4-oxadiazole hybrid compounds: design, synthesis and antimicrobial assessment

• Anas J. Rasras,
• Mohamed El-Naggar,
• Nesreen A. Safwat and
• Raed A. Al-Qawasmeh

Beilstein J. Org. Chem. 2022, 18, 631–638, doi:10.3762/bjoc.18.63

• against the pathogenic fungal strains Aspergillus fumigatus and Candida albicans. The sensitivity of the organisms was assayed against the activity of tested compounds solutions (at 10 mg/mL concentration) using a modified agar well diffusion method with determination of the inhibition zone diameter in mm

• antibacterial activity against Escherichia coli was 4c, 4p, 4d, 4i, 4g, 4t, 4q, 4b, 4j, 4o, 4n, 4s, 4r, and 4l, respectively (Table 1). Moreover, compound 4i exhibited the highest activity against the pathogenic filamentous fungus Aspergillus fumigatus followed by compounds 4s, 4p, 4j, 4q, 4o, 4g, 4k, 4t, 4m

Progress and challenges in the synthesis of sequence controlled polysaccharides

• Giulio Fittolani,
• Theodore Tyrikos-Ergas,
• Denisa Vargová,
• Manishkumar A. Chaube and
• Martina Delbianco

Beilstein J. Org. Chem. 2021, 17, 1981–2025, doi:10.3762/bjoc.17.129

Natural products in the predatory defence of the filamentous fungal pathogen Aspergillus fumigatus

• Jana M. Boysen,
• Nauman Saeed and
• Falk Hillmann

Beilstein J. Org. Chem. 2021, 17, 1814–1827, doi:10.3762/bjoc.17.124

• microbial competitors, symbionts or predators. Here we exemplarily summarize our current knowledge on identified secondary metabolites of the pathogenic fungus Aspergillus fumigatus and their defensive function against (microbial) predators. Keywords: amoeba predation; Aspergillus fumigatus; fungal ecology

• the form of naturally grown truffles (e.g., Tuber melanosporum) or recently cultivated meat alternatives like Quorn® (Fusarium venenatum) [15][16][17]. Species of Aspergillus, such as Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger can affect the health of humans, plants and lifestock

• shown for Aspergillus fumigatus and its interactions with Acanthamoeba castellanii [30]. Thus, the adaptations that protect fungi against amoeba that were gained in the ‘environmental school of virulence’ might also protect fungi from the immune system [31]. Therefore, to study their interactions with

Multicomponent reactions (MCRs): a useful access to the synthesis of benzo-fused γ-lactams

• Edorta Martínez de Marigorta,
• Jesús M. de Los Santos,
• Ana M. Ochoa de Retana,
• Javier Vicario and
• Francisco Palacios

Beilstein J. Org. Chem. 2019, 15, 1065–1085, doi:10.3762/bjoc.15.104

• from Phalaris coerulescens (Figure 3). Likewise, maremycins [13] and spirotryprostatin B [14] have been isolated from marine Streptomyces and from the fermentation broth of Aspergillus fumigatus. Among benzo-fused γ-lactam chemical entities, natural and synthetic isoindolinones are a prominent class of

Influence of per-O-sulfation upon the conformational behaviour of common furanosides

• Alexey G. Gerbst,
• Vadim B. Krylov,
• Dmitry A. Argunov,
• Maksim I. Petruk,
• Arsenii S. Solovev,
• Andrey S. Dmitrenok and
• Nikolay E. Nifantiev

Beilstein J. Org. Chem. 2019, 15, 685–694, doi:10.3762/bjoc.15.63

• , including fragments of a galactomannan from Aspergillus fumigatus [17][18][19], diheteroglycan from Enterococcus faecalis [20], galactan I from Klebsiella pneumoniae [21] and fucoidan from brown seaweed Chordaria flagelliformis [22]. In this communication the conformational analysis of three common per-O

Volatiles from three genome sequenced fungi from the genus Aspergillus

• Jeroen S. Dickschat,
• Ersin Celik and
• Nelson L. Brock

Beilstein J. Org. Chem. 2018, 14, 900–910, doi:10.3762/bjoc.14.77

• genus comprising several hundreds of known species. Some of these species are human pathogens, e.g., Aspergillus fumigatus can cause infections especially in immunocompromised patients, while other species are safe, e.g., Aspergillus oryzae is traditionally used in Japanese sake brewing. The genus has a

O-Alkylated heavy atom carbohydrate probes for protein X-ray crystallography: Studies towards the synthesis of methyl 2-O-methyl-L-selenofucopyranoside

• Roman Sommer,
• Dirk Hauck,
• Annabelle Varrot,
• Anne Imberty,
• Markus Künzler and
• Alexander Titz

Beilstein J. Org. Chem. 2016, 12, 2828–2833, doi:10.3762/bjoc.12.282

• determination [21][22]. This method has now successfully been applied to solve the structure of the bacterial lectins RSL from Ralstonia solanacearum [23], BC2L-C from Burkholderia cenocepacia [24], and the fungal lectin AFL from Aspergillus fumigatus [25] using methyl α-L-selenofucoside (1, Figure 1) as heavy

Encapsulation of biocides by cyclodextrins: toward synergistic effects against pathogens

• Véronique Nardello-Rataj and
• Loïc Leclercq

Beilstein J. Org. Chem. 2014, 10, 2603–2622, doi:10.3762/bjoc.10.273

• nanoparticles were efficient in vitro against P. aeruginosa, S. aureus, Serratia marcescens, E. coli and Klebsiella pneumoniae. In 2011, the same group extended the scope of microorganisms to human opportunistic pathogenic fungi such as Aspergillus fumigatus, Mucor ramosissimus and Chrysosporium species [86

Multicomponent reactions in nucleoside chemistry

• Mariola Koszytkowska-Stawińska and
• Włodzimierz Buchowicz

Beilstein J. Org. Chem. 2014, 10, 1706–1732, doi:10.3762/bjoc.10.179

• of cycloadducts 108 and 109 in molar ratios varied from 1:1 to 12:1. Compounds 108 were inactive against Aspergillus fumigatus or Candida albicans at concentration of 125 µg/mL. Nucleoside analogs 110 with the 3,4-dihydroquinazoline-derived nucleobase were obtained by Siddiqui et al. under microwave

The regioselective synthesis of spirooxindolo pyrrolidines and pyrrolizidines via three-component reactions of acrylamides and aroylacrylic acids with isatins and α-amino acids

• Tatyana L. Pavlovskaya,
• Fedor G. Yaremenko,
• Victoria V. Lipson,
• Svetlana V. Shishkina,
• Oleg V. Shishkin,
• Vladimir I. Musatov and
• Alexander S. Karpenko

Beilstein J. Org. Chem. 2014, 10, 117–126, doi:10.3762/bjoc.10.8

• commutatа [4], mitraphylline from Uncaria tomentosa [5] and spirotryprostatines A and B from the secondary metabolites of Aspergillus fumigatus [6][7][8]. In particular, oxindole derivatives are well known as powerful anti-tumor agents due to their kinase inhibitory properties, especially as tyrosine kinase

The diketopiperazine-fused tetrahydro-β-carboline scaffold as a model peptidomimetic with an unusual α-turn secondary structure

• Francesco Airaghi,
• Andrea Fiorati,
• Giordano Lesma,
• Manuele Musolino,
• Alessandro Sacchetti and
• Alessandra Silvani

Beilstein J. Org. Chem. 2013, 9, 147–154, doi:10.3762/bjoc.9.17

• has led to new classes of biologically active tetracyclic compounds, both naturally occurring and synthetically made [18]. Highly complex natural products displaying the fused, tetracyclic THBC-DKP ring system were recently isolated from the fungus Aspergillus fumigatus [19] and have been shown to

A macrolactonization approach to the total synthesis of the antimicrobial cyclic depsipeptide LI-F04a and diastereoisomeric analogues

• James R. Cochrane,
• Dong Hee Yoon,
• Christopher S. P. McErlean and
• Katrina A. Jolliffe

Beilstein J. Org. Chem. 2012, 8, 1344–1351, doi:10.3762/bjoc.8.154

• . The antifungal activity of 1 and 20–23 was evaluated by using a standardised serial dilution sensitivity assay [28] against reference strains of Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus (Table 3). Synthetic LI-F04a was found to exhibit good activity against both C. albicans

Synthesis and characterization of new diiodocoumarin derivatives with promising antimicrobial activities

• Hany M. Mohamed,
• Ashraf H. F. Abd EL-Wahab,
• Ahmed M. EL-Agrody,
• Ahmed H. Bedair,
• Fathy A. Eid,
• Mostafa M. Khafagy and
• Kamal A. Abd-EL-Rehem

Beilstein J. Org. Chem. 2011, 7, 1688–1696, doi:10.3762/bjoc.7.199

• bacteria, namely Staphylococcus aureus (NCTC-7447), Bacillus cereus (ATCC-14579), and two Gram-negative bacteria, namely Escherichia coli (NCTC-10410), Serratia marcescens (IMRU-70); and against two species of fungi, namely Aspergillus fumigatus (MTCC-3008) and Candida albicans (MTCC-227). The tested