Synthesis and biological evaluation of new brassinosteroid analogs with C-22 benzoate function

• María Núñez,
• Camila Escobar,
• Mario Párraga,
• Mauricio Soto,
• Luis Espinoza-Catalán,
• Katy Díaz and
• Andrés F. Olea

Beilstein J. Org. Chem. 2026, 22, 753–762, doi:10.3762/bjoc.22.57

• . Keywords: biological activity; brassinosteroids; BRI1-EMS-Suppressor1; ligand–receptor interaction; structure–activity relationship; Introduction Brassinosteroids (BRs) are phytohormones that are widespread in the plant kingdom, and are found in very low concentrations, i.e., in the of nano- to micromolar

• extracellular part of a receptor kinase, NRI1, and then the activated BRI1 initiates a series of processes comprising the transduction pathway of BRs [3][15]. The main consequence of this mechanism is the accumulation of two transcription factors: BZR1 (Brassinazole Resistant1) and BES1 (BRI1-EMS-Suppressor1