Natural resorcylic lactones derived from alternariol

• Joachim Podlech

Beilstein J. Org. Chem. 2024, 20, 2171–2207, doi:10.3762/bjoc.20.187

• from an unidentified endophytic fungus [124] and later from colletotrichum sp. [125], Lachnum abnorme [126], Diaporthe phragmitis [127] and a further D. sp. [128], and deviantly from the flower buds of the banana species Musa nana [129]. Its structure was determined by NMR spectroscopy [126] and

• found in Diaporthe cameroonensis [143]. No biological activities were determined for these compounds (Figure 7). A number of sulfate conjugates have been synthesized and used as standards for mass-spectrometric or HPLC analyses [134][141][144]. In this course it turned out that 3-O-sulfates of

• and the respective O-derivatives: 2-Hydroxyalternariol (17) and the respective 9-O-methyl derivative 18 were identified in the human, rat, and porcine metabolism [102][103][150], but 17 was later similarly isolated as a fungal natural product from Diaporthe (Phomopsis) sp. [128][151][152][153][154

Secondary metabolites of Diaporthe cameroonensis, isolated from the Cameroonian medicinal plant Trema guineensis

• Bel Youssouf G. Mountessou,
• Élodie Gisèle M. Anoumedem,
• Blondelle M. Kemkuignou,
• Yasmina Marin-Felix,
• Frank Surup,
• Marc Stadler and
• Simeon F. Kouam

Beilstein J. Org. Chem. 2023, 19, 1555–1561, doi:10.3762/bjoc.19.112

• Abstract From a fresh root of Trema guineensis (Ulmaceae), endophytic fungi were isolated, among which a taxon belonging to the new species Diaporthe cameroonensis. This strain was fermented in shake flask batch cultures and the broth was extracted with ethyl acetate. From the crude extract, a hemiketal

• polyketide 1, and an acetylated alternariol 2 were isolated, along with fifteen known secondary metabolites. Their structures were established by extensive NMR spectroscopy and mass spectrometry analyses, as well as by comparison with literature data of their analogs. Keywords: alternariol; Diaporthe

• chemical constituents of another new species of Diaporthe. This genus contains many plant pathogenic, endophytic, and saprobic species [7]. So far, the investigations of chemical constituents of Diaporthe species, have led to the isolation and characterization of a myriad of potent natural products with

Muyocopronones A and B: azaphilones from the endophytic fungus Muyocopron laterale

• Ken-ichi Nakashima,
• Junko Tomida,
• Tomoe Tsuboi,
• Yoshiaki Kawamura and
• Makoto Inoue

Beilstein J. Org. Chem. 2020, 16, 2100–2107, doi:10.3762/bjoc.16.177

• classes Eutiomycetes (e.g., Monascus, Penicillium, and Aspergillus spp.) and Sordariomycetes (e.g., Chaetomium, Hypoxylon, and Diaporthe spp.) [5]. In addition, some of the azaphilones have been also found in the Dothideomycetes class such as Pithomyces [6], Cochliobolus [7][8], and Leptosphaeria spp. [9

New terpenoids from the fermentation broth of the edible mushroom Cyclocybe aegerita

• Frank Surup,
• Florian Hennicke,
• Nadine Sella,
• Maria Stroot,
• Steffen Bernecker,
• Sebastian Pfütze,
• Marc Stadler and
• Martin Rühl

Beilstein J. Org. Chem. 2019, 15, 1000–1007, doi:10.3762/bjoc.15.98

• in O. olearius [17], Stereum hirsutum [19] and Diaporthe sp. [20] the illudin precursor Δ6-protoilludene undergoes subsequent reactions catalyzed by enzymes, whose genes cluster with the Δ6-protoilludene synthase. Nevertheless, evidence is still missing. In C. aegerita, Δ6-protoilludene is seemingly