N-Salicyl-amino acid derivatives with antiparasitic activity from Pseudomonas sp. UIAU-6B

• Joy E. Rajakulendran,
• Emmanuel Tope Oluwabusola,
• Michela Cerone,
• Terry K. Smith,
• Olusoji O. Adebisi,
• Adefolalu Adedotun,
• Gagan Preet,
• Sylvia Soldatou,
• Hai Deng,
• Rainer Ebel and
• Marcel Jaspars

Beilstein J. Org. Chem. 2025, 21, 1388–1396, doi:10.3762/bjoc.21.103

• remaining compounds showed activity at the highest concentrations tested. The plausible biosynthetic hypotheses toward the compounds were also proposed. Keywords: antiparasitic activity; biosynthesis pathway; phenolic siderophores; Pseudomonas species; pseudomonine; Introduction Species of the genus

Isolation and characterization of new phenolic siderophores with antimicrobial properties from Pseudomonas sp. UIAU-6B

• Emmanuel T. Oluwabusola,
• Olusoji O. Adebisi,
• Fernando Reyes,
• Kojo S. Acquah,
• Mercedes De La Cruz,
• Larry L. Mweetwa,
• Joy E. Rajakulendran,
• Digby F. Warner,
• Deng Hai,
• Rainer Ebel and
• Marcel Jaspars

Beilstein J. Org. Chem. 2021, 17, 2390–2398, doi:10.3762/bjoc.17.156

• pseudomonine [28] are produced under iron deficiency by various Pseudomonas species to acquire iron which is essential for cell metabolism and growth [29][30]. Studies show that siderophore–antibiotic complexes may be used as a Trojan horse strategy in which the antibiotics utilize the iron-siderophore

Synthesis and biological activity of methylated derivatives of the Pseudomonas metabolites HHQ, HQNO and PQS

• Sven Thierbach,
• Max Wienhold,
• Susanne Fetzner and
• Ulrich Hennecke

Beilstein J. Org. Chem. 2019, 15, 187–193, doi:10.3762/bjoc.15.18

• )-quinolones (AQs) have been identified as natural products produced by higher plants of the Rutaceae family as well as by some microorganisms including Alteromonas, Burkholderia and Pseudomonas species [1][2][3][4][5][6][7][8][9]. Plant-derived AQs occur with alkyl chains of different lengths, branches and

Biosynthesis of α-pyrones

• Till F. Schäberle

Beilstein J. Org. Chem. 2016, 12, 571–588, doi:10.3762/bjoc.12.56

• different locations in the genome sequences of the different Pseudomonas species: On a taxonomic level closely related strains harbor the ppyS homologue in the same region of their genome. Therefore, it can be assumed that the genetic information coding for the enzyme needed to synthesize pseudopyronines

• was acquired several times. Hence, Pseudomonas species from different habitats, e.g., rhizosphere, soil, water, acquired the gene set independently [86]. In summary different types of chain-interconnecting KSs which catalyze α-pyrone ring formation were identified in the last years. One mechanism is

Recent highlights in biosynthesis research using stable isotopes

• Jan Rinkel and
• Jeroen S. Dickschat

Beilstein J. Org. Chem. 2015, 11, 2493–2508, doi:10.3762/bjoc.11.271

• study the sulfur source in tropodithietic acid (TDA, 74, Scheme 13) biosynthesis [78]. TDA is a marine antibiotic which was originally isolated from Pseudomonas species [79] showing no observable resistance in important pathogens up to now [80]. The biosynthesis of the tropone core proceeds via the

New modification of the Perkow reaction: halocarboxylate anions as leaving groups in 3-acyloxyquinoline- 2,4(1H,3H)-dione compounds

• Oldřich Paleta,
• Karel Pomeisl,
• Stanislav Kafka,
• Antonín Klásek and
• Vladislav Kubelka

Beilstein J. Org. Chem. 2005, 1, No. 17, doi:10.1186/1860-5397-1-17

• fluorinated but-2-enolide rings. The 3-alkyl-3-hydroxyquinoline-2,4(1H,3H)-dione metabolites of Pseudomonas species exhibit antibiotic or lipoxygenase inhibitor activity[1] that may be modified by the introduction of an annulated pharmacophoric but-2-enolide ring. [2] The annulation was successfully carried