Methyltransferases from RiPP pathways: shaping the landscape of natural product chemistry

• Maria-Paula Schröder,
• Isabel P.-M. Pfeiffer and
• Silja Mordhorst

Beilstein J. Org. Chem. 2024, 20, 1652–1670, doi:10.3762/bjoc.20.147

• -translational modifications; ribosomal peptides; SAM-dependent enzymes; Introduction In the complex landscape of natural product biosynthesis, ribosomally synthesised and post-translationally modified peptides (RiPPs) stand out as a fascinating class of compounds with both structural diversity and unique

• regeneration, adenine or adenosine can be recycled to ATP, and ʟ-homocysteine can be remethylated to ʟ-methionine [21][25]. The SAM regeneration system is not only applicable to conventional SAM-dependent MTs but also to rSAM MTs and other SAM-dependent enzymes, such as amino-propyltransferases [26