Supramolecular polymerization of sulfated dendritic peptide amphiphiles into multivalent L-selectin binders

• David Straßburger,
• Svenja Herziger,
• Katharina Huth,
• Moritz Urschbach,
• Rainer Haag and
• Pol Besenius

Beilstein J. Org. Chem. 2021, 17, 97–104, doi:10.3762/bjoc.17.10

• and microscopic investigations of the aqueous self-assembly behavior of the sulfated peptide amphiphile revealed an ionic strength-dependent formation of one-dimensional anisotropic supramolecular polymers, whereas the non-ionic tetra(ethylene glycol)-decorated analog showed supramolecular

• self-assembly turns out to be crucial in obtaining supramolecular polymers suitable for interactions with biological targets [16]. Peptide amphiphiles provide access to supramolecular structures in this competitive environment by taking advantage of nature’s versatile toolbox of noncovalent

• polymers as a promising class of synthetic scaffolds [10][11][12][13][14]. Supramolecular polymers do provide additional features like a high degree of flexibility and excellent adaptivity, which are critical in biological interactions [15]. As water is the dominant solvent in biological systems, aqueous

Control over size, shape, and photonics of self-assembled organic nanocrystals

• Chen Shahar,
• Yaron Tidhar,
• Yunmin Jung,
• Haim Weissman,
• Sidney R. Cohen,
• Ronit Bitton,
• Iddo Pinkas,
• Gilad Haran and
• Boris Rybtchinski

Beilstein J. Org. Chem. 2021, 17, 42–51, doi:10.3762/bjoc.17.5

• ]. We have reported on 2D crystalline self-assembled systems based on a hierarchical assembly mode promoted by hydrophobic and π–π interactions [36]. Yet, the size and shape of these systems could not be controlled beyond the 2D morphology. We report herein on the aqueous self-assembly of organic

• ][37][38]. Additionally, the aqueous self-assembly incorporating carboxylic acid groups in the covalent unit design has been shown to result in complex and tunable self-assembly modes [39][40][41][42]. Crystalline self-assembly We have found that the nonclassical crystallization of 1 in neutral aqueous

pH- and concentration-dependent supramolecular self-assembly of a naturally occurring octapeptide

• Goutam Ghosh and
• Gustavo Fernández

Beilstein J. Org. Chem. 2020, 16, 2017–2025, doi:10.3762/bjoc.16.168

• development of novel drug nanocarrier assemblies. Keywords: aqueous self-assembly; pH-responsive systems; secondary structure; self-assembled nanostructures; solid-phase peptide synthesis; Introduction The self-assembly of small molecules is a ubiquitous phenomenon in nature [1] and also has key

• renders PEP-1 amphiphilic in nature, which is expected to be beneficial for aqueous self-assembly. The polar Glu and Arg motifs are also sensitive towards basic and acidic pH values, respectively. PEP-1 is actually a naturally occurring β-strand peptide fragment (residues 16−23 in Figure S1, Supporting