Diastereoselective and enantioselective reduction of tetralin- 1,4-dione

• E. Peter Kündig and
• Alvaro Enriquez-Garcia

Beilstein J. Org. Chem. 2008, 4, No. 37, doi:10.3762/bjoc.4.37

• (81%, 95% ee). Conclusion Diastereoselective and enantioselective reductions of the unexplored tetralin-1,4-dione provides a very convenient entry into a number of synthetically highly attractive 1,4-tetralindiols and 4-hydroxy-1-tetralone. Keywords: asymmetric; catalysis; ketone; reduction; tautomer

C₂-symmetric bisamidines: Chiral Brønsted bases catalysing the Diels- Alder reaction of anthrones

• Deniz Akalay,
• Gerd Dürner,
• Jan W. Bats and
• Michael W. Göbel

Beilstein J. Org. Chem. 2008, 4, No. 28, doi:10.3762/bjoc.4.28

• a cycloaddition step stereoselectively controlled by the chiral ion pair. Keywords: Asymmetric Catalysis; Bisamidines; Brønsted base; Diels-Alder reaction; Organocatalysis; Introduction The cycloadditions of anthrones 1 and N-substituted maleimides 2 are prominent examples of asymmetric catalysis

DBFOX- Ph/metal complexes: Evaluation as catalysts for enantioselective fluorination of 3-(2-arylacetyl)-2-thiazolidinones

• Takehisa Ishimaru,
• Norio Shibata,
• Dhande Sudhakar Reddy,
• Takao Horikawa,
• Shuichi Nakamura and
• Takeshi Toru

Beilstein J. Org. Chem. 2008, 4, No. 16, doi:10.3762/bjoc.4.16

• availability of commonly used classes of ligands for asymmetric catalysis, such as, TADDOLs [37][39][41][47], BINAPs [38][40][43][44][46][49][51][53][55][56][57] and bis(oxazoline) [33][34][36][42][45]. Of particular importance are BINAP ligands. Sodeoka et al. have used the latter ligands in asymmetric

The use of chiral lithium amides in the desymmetrisation of N-trialkylsilyl dimethyl sulfoximines

• Matthew J. McGrath and
• Carsten Bolm

Beilstein J. Org. Chem. 2007, 3, No. 33, doi:10.1186/1860-5397-3-33

• potential for use in asymmetric catalysis. Results Asymmetric deprotonation of N-trialkylsilyl dimethyl sulfoximines with either enantiomer of lithium N,N-bis(1-phenylethyl)amide in the presence of lithium chloride affords enantioenriched sulfoximines on electrophilic trapping. Ketones, ketimines

• dimethyl sulfoximines is possible. Introduction The preparation of enantioenriched sulfoximines is an important goal in synthesis as these S-chiral compounds make interesting ligands for asymmetric catalysis and have been used in the construction of pseudopeptides. [1][2][3][4] Enantiomerically enriched

Conformational rigidity of silicon- stereogenic silanes in asymmetric catalysis: A comparative study

• Sebastian Rendler and
• Martin Oestreich

Beilstein J. Org. Chem. 2007, 3, No. 9, doi:10.1186/1860-5397-3-9

• stereochemical outcome of both diastereoselective carbon-silicon and silicon-oxygen bond formation. Based on this insight, further research will be devoted to the extension chiral silicon-based asymmetric catalysis. Cyclic and acyclic sterically encumbered silanes. Cyclic and acyclic chiral silanes as potent

Mixtures of monodentate P-ligands as a means to control the diastereoselectivity in Rh-catalyzed hydrogenation of chiral alkenes

• Manfred T. Reetz and
• Hongchao Guo

Beilstein J. Org. Chem. 2005, 1, No. 3, doi:10.1186/1860-5397-1-3

• catalytic profiles without the need to prepare new ligands. The application of combinatorial chemical methods in asymmetric catalysis has emerged as a promising area of research, and indeed several reviews covering the subject have appeared.[1][2][3][4][5][6][7][8] It is based on the preparation of

Beilstein Journal of Organic Chemistry

• Jonathan Clayden

Beilstein J. Org. Chem. 2005, 1, No. 1, doi:10.1186/1860-5397-1-1

• still to be discovered. Four years ago, the Nobel prize in chemistry celebrated chemists' achievements in asymmetric catalysis – and even since then the face of catalysis is changing, with for example metathesis and organocatalytic methods constantly breaking into new areas. Synthesis is changing too