Emerging trends in the optimization of organic synthesis through high-throughput tools and machine learning

• Pablo Quijano Velasco,
• Kedar Hippalgaonkar and
• Balamurugan Ramalingam

Beilstein J. Org. Chem. 2025, 21, 10–38, doi:10.3762/bjoc.21.3

• categorical and continuous variables, in particular for the stoichiometry and chemical formulation of reaction mixtures. Many HTE batch experiments have been performed in self-contained automated platforms developed by various instrument manufacturers (Chemspeed, Zinsser Analytic, Mettler Toledo, Tecan

• of five small organic molecules, four oligopeptides, and four oligonucleotides in high purity and impressive yield. Although, in the current configuration, the platform lacks characterization modules and has a lower throughput in comparison to other automated platforms, it does offer a low-cost

Homogeneous continuous flow nitration of O-methylisouronium sulfate and its optimization by kinetic modeling

• Jiapeng Guo,
• Weike Su and
• An Su

Beilstein J. Org. Chem. 2024, 20, 2408–2420, doi:10.3762/bjoc.20.205

• , thus providing an efficient guide to optimize reaction conditions [12]. Taylor et al. [13] and Bures et al. [14] have performed kinetic modeling with data collected from continuous flow systems with automated platforms. Yao et al. constructed a kinetic model on thermal dissociation and oligomerization

Progress and challenges in the synthesis of sequence controlled polysaccharides

• Giulio Fittolani,
• Theodore Tyrikos-Ergas,
• Denisa Vargová,
• Manishkumar A. Chaube and
• Martina Delbianco

Beilstein J. Org. Chem. 2021, 17, 1981–2025, doi:10.3762/bjoc.17.129

A recursive microfluidic platform to explore the emergence of chemical evolution

• David Doran,
• Marc Rodriguez-Garcia,
• Rebecca Turk-MacLeod,
• Geoffrey J. T. Cooper and
• Leroy Cronin

Beilstein J. Org. Chem. 2017, 13, 1702–1709, doi:10.3762/bjoc.13.164

• : artificial life; autocatalysis; automated platforms; chemical evolution; evolution before genes; evolution first; microfluidics; Introduction The transition from an inanimate inorganic world, principally consisting of minerals, gases and small organic compounds, to the living world with the first life forms

Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic

• Chinmay A. Shukla and
• Amol A. Kulkarni

Beilstein J. Org. Chem. 2017, 13, 960–987, doi:10.3762/bjoc.13.97