Antibiofilm and cytotoxic metabolites from the entomopathogenic fungus Samsoniella aurantia

• Rita Toshe,
• Syeda J. Khalid,
• Blondelle Matio Kemkuignou,
• Esteban Charria-Girón,
• Paul Eckhardt,
• Birthe Sandargo,
• Kunlapat Nuchthien,
• J. Jennifer Luangsa-ard,
• Till Opatz,
• Hedda Schrey,
• Sherif S. Ebada and
• Marc Stadler

Beilstein J. Org. Chem. 2025, 21, 327–339, doi:10.3762/bjoc.21.23

• activity, inhibiting approximately 70% of Staphylococcus aureus biofilms at concentrations as low as 3.9 µg/mL. Keywords: antibiofilm; antiproliferative; beauvericin; insect pathogen; Samsoniella; Introduction A microbial biofilm represents an assemblage of planktonic cells to overcome hostile living

• . Beauvericin A (4): Yellow solid powder; UV–vis (MeOH) λmax: 344, 221 nm; NMR data (1H: 500 MHz in DMSO-d6) comparable to the previously described spectral data [14][15]; HRESIMS m/z: [M + H]+ calcd for C46H60N3O9+, 798.4324; found, 798.4324; [M + NH4]+ calcd for C46H63N4O9+, 815.4590; found, 815.4588; [M + Na

• ]+ calcd for C46H59N3NaO9+, 820.4144; found, 820.4142. Beauvericin B (5): Yellow amorphous solid; UV–vis (MeOH) λmax: 344, 250, 210 nm; NMR data (1H: 500 MHz, DMSO-d6) comparable to the previously described spectral data [14][15]; HRESIMS m/z: [M + H]+ calcd for C47H62N3O9+, 812.4481; found, 812.4489; [M

Pigmentosins from Gibellula sp. as antibiofilm agents and a new glycosylated asperfuran from Cordyceps javanica

• Soleiman E. Helaly,
• Wilawan Kuephadungphan,
• Patima Phainuphong,
• Mahmoud A. A. Ibrahim,
• Kanoksri Tasanathai,
• Suchada Mongkolsamrit,
• Janet Jennifer Luangsa-ard,
• Souwalak Phongpaichit,
• Vatcharin Rukachaisirikul and
• Marc Stadler

Beilstein J. Org. Chem. 2019, 15, 2968–2981, doi:10.3762/bjoc.15.293

• close to each other [23], and they produce the same secondary metabolites according to the evidence from Kadlec and co-workers [24], Jegorov and co-workers [25], and Luangsa-ard and co-workers [26]. They unveiled the existences of beauverolides and beauvericin, originally described from Beauveria, in

Natural products from microbes associated with insects

• Christine Beemelmanns,
• Huijuan Guo,
• Maja Rischer and
• Michael Poulsen

Beilstein J. Org. Chem. 2016, 12, 314–327, doi:10.3762/bjoc.12.34

• D-serine. Due to the presence in conidia, serinocyclines have also been hypothesized to play a role in the virulence of M. anisopliae. Chemical analysis of the entomopathogenic fungus B. bassiana yielded beauvericin (43), a depsipeptide with alternating methylphenylalanyl and hydroxyisovaleryl

• residues. Beauvericin has antibacterial, antifungal, and insecticidal activities, in addition to its potent cytotoxic activity against human cell lines [130]; attributes which indicate a crucial role in the infection process. The red 1,4-bibenzoquinone derivative oosporein (44) was first identified in the

• (38), paraconfuranone A (39), and ilicicolinic acid A (40). Predatory interactions, (1) entomopathogenic fungi use insect as prey. Entomopathogenic fungi use secondary metabolites as insecticidal compounds to kill their prey. Destruxin A (41), serinocyclin A (42), beauvericin (43), and oosporein (44