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Search for "catalyst-free synthesis" in Full Text gives 9 result(s) in Beilstein Journal of Organic Chemistry.
High-pressure activation for the solvent- and catalyst-free syntheses of heterocycles, pharmaceuticals and esters
Beilstein J. Org. Chem. 2025, 21, 1374–1387, doi:10.3762/bjoc.21.102
- -products. A computational study accompanies the experimental data to interpret the outcome of the reactions. Keywords: acetaminophen; acetylsalicylic acid; benzimidazoles; catalyst-free synthesis; cyclization; esters; high hydrostatic pressure; pyrazoles; Introduction Non-traditional activation methods
Clauson–Kaas pyrrole synthesis using diverse catalysts: a transition from conventional to greener approach
Beilstein J. Org. Chem. 2023, 19, 928–955, doi:10.3762/bjoc.19.71
- -SO3H-catalyzed synthesis and proposed mechanism of pyrroles 37. Solvent-free and catalyst-free synthesis and plausible mechanism of N-substituted pyrroles 39. Nano-sulfated TiO2-catalyzed synthesis of N-substituted pyrroles 41. Copper nitrate-catalyzed Clauson–Kaas synthesis and mechanism of N
Menadione: a platform and a target to valuable compounds synthesis
Beilstein J. Org. Chem. 2022, 18, 381–419, doi:10.3762/bjoc.18.43
A novel three-component reaction between isocyanides, alcohols or thiols and elemental sulfur: a mild, catalyst-free approach towards O-thiocarbamates and dithiocarbamates
Beilstein J. Org. Chem. 2019, 15, 1523–1533, doi:10.3762/bjoc.15.155
- been developed between isocyanides, sulfur and alcohols or thiols under mild reaction conditions to afford O-thiocarbamates and dithiocarbamates in moderate to good yields. The one-pot reaction cascade involves the formation of an isothiocyanate intermediate, thus a catalyst-free synthesis of
- , we have developed an efficient, convenient and scalable multicomponent method for the synthesis of O-thiocarbamates and dithiocarbamates under mild reaction conditions. This approach includes an improved catalyst-free synthesis of isothiocyanates from elemental sulfur and isocyanides, and shows good
Annulation of 1H-pyrrole-2,3-diones by thioacetamide: an approach to 5-azaisatins
Beilstein J. Org. Chem. 2019, 15, 364–370, doi:10.3762/bjoc.15.32
- and Discussion Previously, we reported an efficient catalyst-free synthesis of spiro[thiazolo-5,2'-pyrroles] 1 via interaction of pyrrolobenzoxazinetriones (PBTs) 2 with thiobenzamide (Scheme 2) [17][18]. In continuation of this research [17][18], and in order to extend the scope of the reaction, we
Catalyst-free synthesis of 4-acyl-NH-1,2,3-triazoles by water-mediated cycloaddition reactions of enaminones and tosyl azide
Beilstein J. Org. Chem. 2018, 14, 2348–2353, doi:10.3762/bjoc.14.210
- -triazoles [56][57][58][59][60][61] as well as the urgent desire in finding more sustainable methods enabling 1,2,3-triazole synthesis, we report herein our results in the water-mediated, catalyst-free synthesis of NH-1,2,3-triazoles through the cycloaddition of enaminone and sulfonyl azide with mild heating
Mechanochemical synthesis of thioureas, ureas and guanidines
Beilstein J. Org. Chem. 2017, 13, 1828–1849, doi:10.3762/bjoc.13.178
- ). Sulfonylureas could also be obtained by coupling of sulfonyl isocyanates with amines which was demonstrated by an efficient solvent-, base- and catalyst-free synthesis of tolbutamide (93%) starting from p-toluenesulfonyl isocyanate and n-butylamine. However, this approach was not further pursued due to the air
Effect of the ortho-hydroxy group of salicylaldehyde in the A3 coupling reaction: A metal-catalyst-free synthesis of propargylamine
Beilstein J. Org. Chem. 2017, 13, 552–557, doi:10.3762/bjoc.13.53
A one-pot catalyst-free synthesis of functionalized pyrrolo[1,2-a]quinoxaline derivatives from benzene-1,2-diamine, acetylenedicarboxylates and ethyl bromopyruvate
Beilstein J. Org. Chem. 2013, 9, 510–515, doi:10.3762/bjoc.9.55
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