Bioinspired total syntheses of natural products: a personal adventure

• Zhengyi Qin,
• Yuting Yang,
• Nuran Yan,
• Xinyu Liang,
• Zhiyu Zhang,
• Yaxuan Duan,
• Huilin Li and
• Xuegong She

Beilstein J. Org. Chem. 2025, 21, 2048–2061, doi:10.3762/bjoc.21.160

• , bioinspired total synthesis of three types of natural products, namely diterpenoids (chabranol, and monocerin), alkaloids (indole, hydroquinoline, and monoterpenoid−indolidinoid hybrid), and gymnothelignans are discussed. Based on these achievements on bioinspired total synthesis, we provide some information

• on how to use this important strategy in natural product synthesis. Keywords: bioinspired total synthesis; chabranol; gymnothelignans; monocerin; sarglamides; taberginggine; Introduction Natural products are chemical substances generated within living organisms in nature. They are products of

• synthesis of natural products. Review Synthesis of chabranol In 2009, Duh and co-workers investigated the ingredients of Formosan soft corals Sinularia capillosa Tixier-Durivault and Nephthea chabroli Audouin, collected from west pacific Dongsha Atoll and Siaoliouciou Island, providing two terpenoid natural