Palladium-catalyzed benzocyclization reactions of quinoline-2-carboxamides via sequential C–H/N–H functionalization

• Shoichi Sugita,
• Kentaro Okano and
• Atsunori Mori

Beilstein J. Org. Chem. 2026, 22, 905–914, doi:10.3762/bjoc.22.71

• corresponding heterocycle-fused compounds. The high chemoselectivity of the 1,2-dihaloarene functional groups is confirmed in this reaction, thus enabling divergent synthesis of various multifused heterocyclic systems. Keywords: C–H activation; chemodivergent synthesis; C–N coupling; fused-ring system

• -metal catalysts. This can reveal their selectivity in terms of reaction position(s) in chemodivergent synthesis (Scheme 2c). The present report explores benzocyclization reactions involving sequential C–H/N–H functionalization by a palladium catalyst. Results and Discussion First, the C–H/N–H annulation