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Search for "cofactor-independent oxygenase" in Full Text gives 1 result(s) in Beilstein Journal of Organic Chemistry.

Cofactor-independent C–C bond cleavage reactions catalyzed by the AlpJ family of oxygenases in atypical angucycline biosynthesis

  • Jinmin Gao,
  • Liyuan Li,
  • Shijie Shen,
  • Guomin Ai,
  • Bin Wang,
  • Fang Guo,
  • Tongjian Yang,
  • Hui Han,
  • Zhengren Xu,
  • Guohui Pan and
  • Keqiang Fan

Beilstein J. Org. Chem. 2024, 20, 1198–1206, doi:10.3762/bjoc.20.102

Graphical Abstract
  • cofactor-independent manner. Keywords: angucyclines; aromatic polyketide; biosynthesis; cofactor-independent oxygenase; oxidative rearrangement reaction; Introduction The angucyclines represent a large class of natural products biosynthesized by type II polyketide synthases. Within this category, a
  • catalytic mechanism employed by AlpJ-family oxygenases, wherein the nature of the substrate dictates whether a cofactor-dependent or -independent reaction ensues. While it is not entirely unexpected that these enzymes could exhibit cofactor-independent oxygenase activity, given our prior discovery that the
  • cofactor-independent pathway is likely the favored biosynthetic route in the angucycline biosynthesis process. Conclusion In this study, we showed that AlpJ-family oxygenases, traditionally recognized as FADH2/FMNH2-dependent enzymes, exhibit cofactor-independent oxygenase activity when 8 is employed as
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Published 23 May 2024
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