Search results
Search for "copper(I)-catalyzed alkyne–azide cycloaddition" in Full Text gives 6 result(s) in Beilstein Journal of Organic Chemistry.
Active-metal template clipping synthesis of novel [2]rotaxanes
Beilstein J. Org. Chem. 2023, 19, 1776–1784, doi:10.3762/bjoc.19.130
- of the final [2]rotaxanes by active template copper(I)-catalyzed alkyne–azide cycloaddition (CuAAC) as key step of the synthesis. HRMS and NMR experiments have been performed to confirm the formation of the interlocked structures. Keywords: active-metal template; clipping; copper(I)-catalyzed alkyne
- –azide cycloaddition; mechanically interlocked structures; [2]rotaxanes; Introduction Since its birth, in the late sixties [1][2][3], the field of mechanically interlocked molecules (MIMs), including rotaxanes, has gained significant attention culminating by recognition with a Nobel prize in Chemistry
Targeting the Pseudomonas quinolone signal quorum sensing system for the discovery of novel anti-infective pathoblockers
Beilstein J. Org. Chem. 2018, 14, 2627–2645, doi:10.3762/bjoc.14.241
- , a novel competition assay employing ‘clickable’ active-site-labelling probes was developed. These compounds contain terminal alkyne moieties, which can be exploited for straightforward decoration via copper(I)-catalyzed alkyne–azide cycloaddition (CuAAC), the prototypic click reaction. This
An amphiphilic pseudo[1]catenane: neutral guest-induced clouding point change
Beilstein J. Org. Chem. 2018, 14, 1937–1943, doi:10.3762/bjoc.14.167
- -responsive LCST changes are very rare, while there have been some examples of LCST control using ionic chemical stimuli [5][6]. Results and Discussion Supramolecular structure and clouding point of bicyclic compound 3 The bicyclic compound 3 was prepared using a copper(I)-catalyzed alkyne–azide cycloaddition
Effective ascorbate-free and photolatent click reactions in water using a photoreducible copper(II)-ethylenediamine precatalyst
Beilstein J. Org. Chem. 2015, 11, 1950–1959, doi:10.3762/bjoc.11.211
- Since the discovery in 2002 that copper(I) could catalyze the Huisgen alkyne–azide [3 + 2] cycloaddition with high selectivity for the 1,4-triazole [1][2], the so-called copper(I)-catalyzed alkyne–azide cycloaddition (CuAAC) has become a privileged reaction which is widely employed in all areas of the
Orthogonal dual thiol–chloroacetyl and thiol–ene couplings for the sequential one-pot assembly of heteroglycoclusters
Beilstein J. Org. Chem. 2014, 10, 1557–1563, doi:10.3762/bjoc.10.160
- successive attachment of sugar residues on a core scaffold such as sugar [6][7], peptide [8][9][10], dendrimer [11][12], cyclodextrin [13][14][15] and polymer [16]. The most common synthetic strategy to build such hGCs relies on a fragment-coupling approach using thiol–ene coupling [17], copper(I)-catalyzed
- alkyne–azide cycloaddition (CuAAC) [18] or SN2 reaction [19]. In addition, orthogonal chemoselective ligations were proved more attractive strategies to prepare hGCs in high yields, in part because they require less synthetic and purification steps. For example, oxime and CuAAC ligations have been used
Synthesis of heteroglycoclusters by using orthogonal chemoselective ligations
Beilstein J. Org. Chem. 2012, 8, 421–427, doi:10.3762/bjoc.8.47
- combinations of carbohydrates. By using both oxime ligation and copper(I)-catalyzed alkyne–azide cycloaddition, two series of compounds bearing binary combinations of αMan, αFuc or βLac in an overall tetravalent presentation, and either 2:2 or 3:1 relative proportions, have been prepared. Keywords
- ligands [30] or vectors of hepatocytes [31]. As the second strategy, we have chosen the well-known copper(I)-catalyzed alkyne–azide cycloaddition (CuAAC) [32][33], which is intensively exploited for the conjugation of sugars to both molecular and biological systems [34][35]. Besides being fully compatible
Other Beilstein-Institut Open Science Activities
