Methodology for awakening the potential secondary metabolic capacity in actinomycetes

• Shun Saito and
• Midori A. Arai

Beilstein J. Org. Chem. 2024, 20, 753–766, doi:10.3762/bjoc.20.69

• skeleton in which a substructure of desferrioxamine (DFO, 38), a well-known secondary metabolite [78], is condensed at the end of the steroid skeleton. It is thought that DFO is produced as a result of the activation of a silent gene, whereas the steroid skeleton may be a component of the culture medium

Tenacibactins K–M, cytotoxic siderophores from a coral-associated gliding bacterium of the genus Tenacibaculum

• Yasuhiro Igarashi,
• Yiwei Ge,
• Tao Zhou,
• Amit Raj Sharma,
• Enjuro Harunari,
• Naoya Oku and
• Agus Trianto

Beilstein J. Org. Chem. 2022, 18, 110–119, doi:10.3762/bjoc.18.12

• 50275, Central Java, Indonesia 10.3762/bjoc.18.12 Abstract HPLC/DAD-based chemical investigation of a coral-associated gliding bacterium of the genus Tenacibaculum yielded three desferrioxamine-class siderophores, designated tenacibactins K (1), L (2), and M (3). Their chemical structures, comprising

• submicromolar to micromolar ranges. Their iron-chelating activity was comparable to deferoxamine mesylate. Keywords: desferrioxamine; marine obligate bacterium; MS/MS analysis; tenacibactin; Tenacibaculum; Introduction Marine organisms continue to be a prolific resource of new bioactive natural products that

• saturated congener of compounds 2 and 3. Tenacibactins K−M (1–3) are new members of desferrioxamine-type hydroxamate siderophores [28]. The preceding congeners are tenacibactins A–D produced by Tenacibaculum sp. [18] and tenacibactins E–J produced by Streptomyces sp. [29]. Siderophores of this class are