Palladium-catalyzed three-component radical-polar crossover carboamination of 1,3-dienes or allenes with diazo esters and amines

• Geng-Xin Liu,
• Xiao-Ting Jie,
• Ge-Jun Niu,
• Li-Sheng Yang,
• Xing-Lin Li,
• Jian Luo and
• Wen-Hao Hu

Beilstein J. Org. Chem. 2024, 20, 661–671, doi:10.3762/bjoc.20.59

• multicomponent reaction protocol. Keywords: carboamination; diazo chemistry; palladium catalysis; radical-polar crossover; three-component reaction; Introduction Since the discovery of the existence of non-canonical amino acids (AAs) in organisms, such structural motifs have attracted considerable attention

Access to cyclopropanes with geminal trifluoromethyl and difluoromethylphosphonate groups

• Ita Hajdin,
• Romana Pajkert,
• Mira Keßler,
• Jianlin Han,
• Haibo Mei and
• Gerd-Volker Röschenthaler

Beilstein J. Org. Chem. 2023, 19, 541–549, doi:10.3762/bjoc.19.39

• slight preference for one diastereoisomer. The presented results turn of a new page for the future of diazo chemistry. 19F,1H-HOESY spectrum of compound 6c. Previous works (A–D) and the extension (this work). Synthesis of diethyl 2-diazo-1,1,3,3,3-pentafluoropropylphosphonate (5). Scope of the

Facile and diastereoselective arylation of the privileged 1,4-dihydroisoquinolin-3(2H)-one scaffold

• Dmitry Dar’in,
• Grigory Kantin,
• Alexander Bunev and
• Mikhail Krasavin

Beilstein J. Org. Chem. 2022, 18, 1070–1078, doi:10.3762/bjoc.18.109

• literature. Lured by the prospects of applying a diazo chemistry route to an expedited synthesis of hitherto undescribed 1,2,4-trisubstituted 1,4-DHIQs 9 from 11, we set off to investigate the obtainability of 10 from 11 by the Regitz [21] diazo transfer and the usage of 10 in acid-promoted direct arylation