Electrocatalytic hydrogenation of cyanoarenes, nitroarenes, quinolines, and pyridines under mild conditions with a proton-exchange membrane reactor

• Koichi Mitsudo,
• Atsushi Osaki,
• Haruka Inoue,
• Eisuke Sato,
• Naoki Shida,
• Mahito Atobe and
• Seiji Suga

Beilstein J. Org. Chem. 2024, 20, 1560–1571, doi:10.3762/bjoc.20.139

• of the nitroarene electro-reduction was explored (Scheme 3). To obtain products in high yields, the electrolysis was performed until the substrates were consumed. First, nitroarenes bearing electron-donating groups were investigated. Nitroarenes 4b–d bearing methyl groups gave the corresponding

• was reused eight times, and 7a was obtained in high yield in each run. The addition of pyridinium p-toluenesulfonate (PPTS) was also efficient, and MEA was repeatedly used to afford 7a in high yield (Figure 4). After further tunings, we found that the charge for electro-reduction of 6a could be

Electrogenerated base-promoted cyclopropanation using alkyl 2-chloroacetates

• Kouichi Matsumoto,
• Yuta Hayashi,
• Kengo Hamasaki,
• Mizuki Matsuse,
• Hiyono Suzuki,
• Keiji Nishiwaki and
• Norihito Kawashita

Beilstein J. Org. Chem. 2022, 18, 1116–1122, doi:10.3762/bjoc.18.114

• electrochemical production of cyclopropane derivatives is an environmentally friendly and easy to perform synthetic procedure. Keywords: alkyl 2-chloroacetates; cyclopropane derivatives; divided cell; electro-reduction; Introduction In organic chemistry, cyclopropanes and their related compounds have been