Beyond symmetric self-assembly and effective molarity: unlocking functional enzyme mimics with robust organic cages

• Keith G. Andrews

Beilstein J. Org. Chem. 2025, 21, 421–443, doi:10.3762/bjoc.21.30

• , sometimes under the moniker “enzyme mimic” [22][138]. MOCs are typically soluble in polar organic solvents or water [156][157], and so their dynamics can be studied using solution-phase techniques [22]. Isolation from solution is not always possible, since their dynamic nature can make them sensitive to

Structure–efficiency relationships of cyclodextrin scavengers in the hydrolytic degradation of organophosphorus compounds

• Sophie Letort,
• Michaël Bosco,
• Benedetta Cornelio,
• Frédérique Brégier,
• Sébastien Daulon,
• Géraldine Gouhier and
• François Estour

Beilstein J. Org. Chem. 2017, 13, 417–427, doi:10.3762/bjoc.13.45

• of the agents. The degradation efficiency was found to be dependent on the relative position of the heterocycle towards the reactive group as well as on the nature of the organophosphorus derivative. Keywords: cyclodextrin; decontamination; enzyme mimic; nerve agents; organophosphorus pesticides

From supramolecular chemistry to the nucleosome: studies in biomolecular recognition

• Marcey L. Waters

Beilstein J. Org. Chem. 2016, 12, 1863–1869, doi:10.3762/bjoc.12.175

• – combining peptide chemistry and supramolecular chemistry I learned a great deal of things during my postdoc and it was a great experience for me. However, one thing I learned was that I did not want to start out my independent career trying to design and synthesize a functional molecule (receptor, enzyme

• mimic, etc), only to find out after several months of synthesis that it did not function as planned! I wanted to utilize versatile chemistry that allowed me to synthesize and evaluate the compound of interest quickly and modify it rapidly for further mechanistic studies. This led me to become a peptide

From steroids to aqueous supramolecular chemistry: an autobiographical career review

• Bruce C. Gibb

Beilstein J. Org. Chem. 2016, 12, 684–701, doi:10.3762/bjoc.12.69

• influence on my career, and I can recall two key moments where his wisdom helped point me in the right direction. The first came as we wrote a review on metallo-enzyme mimics [12]. Near the end of the whole process I mentioned to Jim that it was kind of disappointing that when synthesizing an enzyme mimic

Interactions of cyclodextrins and their derivatives with toxic organophosphorus compounds

• Sophie Letort,
• Sébastien Balieu,
• William Erb,
• Géraldine Gouhier and
• François Estour

Beilstein J. Org. Chem. 2016, 12, 204–228, doi:10.3762/bjoc.12.23

• scavengers able to trap and hydrolyze the organophosphorus compounds before they reach their biological target. Keywords: cyclodextrin; enzyme mimic; nerve agents; organophosphorus compounds; pesticides; Introduction Due to their biological activities, organophosphorus compounds have had considerable