Beilstein J. Org. Chem.2025,21, 421–443, doi:10.3762/bjoc.21.30
symmetry to enable promising catalytic modes.
Keywords: cavity confinement catalysis; enzymemimicry; robust organic cages; self-assembly; supramolecular catalysis; Introduction
I frequently introduce my research on organic cage enzyme mimics with the following observation. For hundreds of years
synthesis of self-assembled, robust organic cages with internal functionality [38][39][40][41][42][43][44]. Robust organic cages are under-represented in the supramolecular catalysis and enzyme-mimicry literature, an observation which correlates strongly with the lack of cavity-based organocatalysts. The
PDF
Graphical Abstract
Figure 1:
Catalytic rate enhancements from a reduction in the Gibbs free energy transition barrier can be fra...
Beilstein J. Org. Chem.2012,8, 2132–2141, doi:10.3762/bjoc.8.240
. Organocatalyts also provide an insight into biological catalytic processes, as a number of these catalysts work by the phenomenon of enzymemimicry. These advantages of chiral organocatalysts also meet many of the requirements of green chemistry [27].
Recently developed, organocatalytic asymmetric
PDF
Graphical Abstract
Scheme 1:
Proline-catalysed aldol reaction in a ball-mill.