Fluorogenic PNA probes

• Tirayut Vilaivan

Beilstein J. Org. Chem. 2018, 14, 253–281, doi:10.3762/bjoc.14.17

• bases). In this section, only those that have been used in combination with PNA will be discussed. More general reviews of fluorescent base analogues in the DNA/RNA context can be found elsewhere [177][178]. Fluorescent nucleobases capable of hydrogen bonding ("base discriminating fluorophores") The

Fluorescent nucleobase analogues for base–base FRET in nucleic acids: synthesis, photophysics and applications

• Mattias Bood,
• Sangamesh Sarangamath,
• Moa S. Wranne,
• Morten Grøtli and
• L. Marcus Wilhelmsson

Beilstein J. Org. Chem. 2018, 14, 114–129, doi:10.3762/bjoc.14.7

• . Keywords: B-to-Z-DNA transition; fluorescent base analogues; FRET; netropsin; nucleic acid structure and dynamics; quadracyclic adenines; tricyclic cytosines; Z-DNA; Review Introduction The importance of nucleic acid structure and dynamics in the understanding of vital processes in living organisms has

• . In this review we will focus on the FRET between fluorescent base analogues, i.e., base–base FRET, the theory behind it, the increased accuracy in orientation factor κ2 as an effect of their position inside the base-stack, other advantages and disadvantages compared to FRET in nucleic acids using

• . Unfortunately, the variety of functional groups requires different protection group strategies and, moreover, changes the reactivity of the nucleobase. Since the discovery of the gold standard of fluorescent base analogues, 2-AP, a multitude of adenine FBAs has emerged [22]. Notable recent examples of adenine