Beilstein J. Org. Chem.2025,21, 680–716, doi:10.3762/bjoc.21.54
–C–N alignment is anti, the effect is stronger and the pKaH will be lowered by ≈2 log units. Clearly it is important to bear this in mind when utilising fluorine to optimise the properties of nitrogen-containing drugs.
Having concluded our examination of fluorinatedamines, let us now focus upon some
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Graphical Abstract
Figure 1:
Fundamental characteristics of the C–F bond.
Beilstein J. Org. Chem.2017,13, 728–733, doi:10.3762/bjoc.13.72
elimination. The two all-cis tetrafluorocyclohexyl isomers 5a and 5b constitute facially polarized cyclohexane rings, with fluorines on the electronegative face and hydrogens on the electropositive face.
Keywords: all-cis tetrafluorocyclohexane motif; deoxofluorination reactions; fluorinatedamines
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Graphical Abstract
Figure 1:
The derivatives of all-cis-2,3,5,6-tetrafluorocyclohexane.