Green and sustainable approaches for the Friedel–Crafts reaction between aldehydes and indoles

• Periklis X. Kolagkis,
• Eirini M. Galathri and
• Christoforos G. Kokotos

Beilstein J. Org. Chem. 2024, 20, 379–426, doi:10.3762/bjoc.20.36

• highest fungicidal activity [11]. Brønsted or Lewis acid catalysis – conventional synthetic methods The indole moiety is part of many natural products, agrochemicals, and pharmaceuticals. In medicinal chemistry, indole and its derivatives are considered important compounds, since they exhibit valuable

On the application of 3d metals for C–H activation toward bioactive compounds: The key step for the synthesis of silver bullets

• Renato L. Carvalho,
• Amanda S. de Miranda,
• Mateus P. Nunes,
• Roberto S. Gomes,
• Guilherme A. M. Jardim and
• Eufrânio N. da Silva Júnior

Beilstein J. Org. Chem. 2021, 17, 1849–1938, doi:10.3762/bjoc.17.126

Chemoselective O-acylation of hydroxyamino acids and amino alcohols under acidic reaction conditions: History, scope and applications

• Tor E. Kristensen

Beilstein J. Org. Chem. 2015, 11, 446–468, doi:10.3762/bjoc.11.51

• and O-phenylacetyl derivatives of DL-serine and threo-DL-phenylserine, as reported in 2003 (using the acyl chlorides in CF3CO2H), derivatives that displayed fungicidal activity [40]. However, by and large, the synthesis of amino acid or amino alcohol derivatives has relied on traditional protective

Encapsulation of biocides by cyclodextrins: toward synergistic effects against pathogens

• Véronique Nardello-Rataj and
• Loïc Leclercq

Beilstein J. Org. Chem. 2014, 10, 2603–2622, doi:10.3762/bjoc.10.273

• . In addition, the authors have reported that the complexation of carbendazim with HP-β-CD significantly improves its bioavailability and, therefore, resulting in about a two-fold increase of the fungicidal activity against Trichioderma viride (fungus) compared to carbendazim alone. As a consequence

Synthesis of 2,3-dihydronaphtho[2,3-d][1,3]thiazole-4,9-diones and 2,3-dihydroanthra[2,3-d][1,3]thiazole-4,11-diones and novel ring contraction and fusion reaction of 3H-spiro[1,3-thiazole-2,1'-cyclohexanes] into 2,3,4,5-tetrahydro-1H-carbazole-6,11-diones

• Lidia S. Konstantinova,
• Kirill A. Lysov,
• Ljudmila I. Souvorova and
• Oleg A. Rakitin

Beilstein J. Org. Chem. 2013, 9, 577–584, doi:10.3762/bjoc.9.62

• far, no general approach to their synthesis has been proposed, and yields are often low. 3-Methyl-2-thioxo-2,3-dihydronaphtho[2,3-d][1,3]thiazole-4,9-dione has been shown to possess a fungicidal activity to Pyricularia Oryzae [4][5]. A family of thiazolonaphthoquinones fused on a chain with nitrogen

Derivatives of phenyl tribromomethyl sulfone as novel compounds with potential pesticidal activity

• Krzysztof M. Borys,
• Maciej D. Korzyński and
• Zbigniew Ochal

Beilstein J. Org. Chem. 2012, 8, 259–265, doi:10.3762/bjoc.8.27

• some nitroaniline and benzimidazole derivatives was beneficial to their herbicidal and fungicidal activity [6][8][9]. Moreover, some 2-nitroaniline and 2,6-dinitroaniline derivatives belong to the group of commonly applied herbicides [10]. Herein we report the synthesis of novel aromatic compounds

• with carbon disulfide (Scheme 8) [17]. Moreover, 11h was subjected to the reaction with aromatic isocyanates to give benzimidazolthiocarbamates 11i and 11j. The synthesized compounds were tested for their fungicidal activity. The evaluation was carried out by determining the percentage inhibition of

• of the obtained compounds exhibit fungicidal activity. Retrosynthetic analysis of the designed target molecules. Synthetic routes for 4-chlorophenyl tribromomethyl sulfone (1). Halogenation/nitration sequence for 4-halogenphenyl methyl sulfones 4 and 4'. SNAr transformations of sulfone 6. Preparation

Advances in synthetic approach to and antifungal activity of triazoles

• Kumari Shalini,
• Nitin Kumar,
• Sushma Drabu and
• Pramod Kumar Sharma

Beilstein J. Org. Chem. 2011, 7, 668–677, doi:10.3762/bjoc.7.79

• strain-dependent fungicidal activity against filamentous fungi with the exception of some strains of Cryptococcus neoformans. It is taken orally in capsule form to treat fungal infections that start in the lungs and spread throughout the body. Itraconazole can also be used to treat fungal infections of

• should be avoided in patients taking cyclosporine, rifampicin, carbamazepine, ritonavir and long-acting barbiturates. Various studies have shown that voriconazole is fungistatic and has fungicidal activity against Aspergillus spp. [53]. Antifungal triazoles belong to the class of 14β-demethylase

A facile synthesis and fungicidal activities of 2-(alkylamino)-5,6-dimethylthieno[2,3-d]pyrimidin- 4(3H)-ones

• Yang-Gen Hu,
• Ai-Hua Zheng,
• Xu-Zhi Ruan and
• Ming-Wu Ding

Beilstein J. Org. Chem. 2008, 4, No. 49, doi:10.3762/bjoc.4.49

• activities against six kinds of fungi. Keywords: 2-(alkylamino)-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one; aza-Wittig reaction; fungicidal activity; synthesis; Introduction Over the past ten years, aza-Wittig reactions of functionalized iminophosphoranes with isocyanates have been applied to produce

• listed in Table 1. Fungicidal activity The fungicidal activities of compounds 6 and 8 were screened against six kinds of fungi, Fusarium oxysporum, Rhizoctonia solani, Botrytis cinerea, Gibberella zeae, Dothiorella gregaria, Colletotrichum gossypii at a concentration of 50 mg/L according to the reported