Novel unit B cryptophycin analogues as payloads for targeted therapy

• Eduard Figueras,
• Adina Borbély,
• Mohamed Ismail,
• Marcel Frese and
• Norbert Sewald

Beilstein J. Org. Chem. 2018, 14, 1281–1286, doi:10.3762/bjoc.14.109

• activity of analogue 22 could be due to its poor internalization or the modification could alter the interaction with tubulin. In order to get an extensive knowledge of the novel analogues, we embarked in docking and modelling studies, herein reported, and internalization studies are ongoing in our

Dimerization of a cell-penetrating peptide leads to enhanced cellular uptake and drug delivery

• Jan Hoyer,
• Ulrich Schatzschneider,
• Michaela Schulz-Siegmund and
• Ines Neundorf

Beilstein J. Org. Chem. 2012, 8, 1788–1797, doi:10.3762/bjoc.8.204

• a cell-penetrating peptide. Keywords: anti-tumor agents; cell-penetrating peptides; drug delivery; internalization studies; organometallic complexes; peptides; Introduction A substantial problem concerning promising drug candidates is often their incapacity to reach their full therapeutic

• ) were grown in DMEM high glucose (4.5 g/L) containing 1% penicillin/streptomycin and 10% FBS. Internalization studies For peptide-uptake studies by flow cytometry, cells were seeded in a 48-well plate and grown to 60–70% confluence. After incubation at 37 °C for 1 h with 5(6)-carboxyfluorescein-labeled