Search results

Search for "late-stage functionalisation" in Full Text gives 5 result(s) in Beilstein Journal of Organic Chemistry.

Oxetanes: formation, reactivity and total syntheses of natural products

  • Peter Gabko,
  • Martin Kalník and
  • Maroš Bella

Beilstein J. Org. Chem. 2025, 21, 1324–1373, doi:10.3762/bjoc.21.101

Graphical Abstract
  • , amides or esters and occurs under very mild conditions that are also suitable for a late-stage functionalisation of complex molecules. The transformation is based on an H-atom transfer to photochemically oxidised quinuclidine followed by an annulation of the resulting ketyl radical 32 with
PDF
Album
Review
Published 27 Jun 2025

Investigations of amination reactions on an antimalarial 1,2,4-triazolo[4,3-a]pyrazine scaffold

  • Henry S. T. Smith,
  • Ben Giuliani,
  • Kanchana Wijesekera,
  • Kah Yean Lum,
  • Sandra Duffy,
  • Aaron Lock,
  • Jonathan M. White,
  • Vicky M. Avery and
  • Rohan A. Davis

Beilstein J. Org. Chem. 2025, 21, 1126–1134, doi:10.3762/bjoc.21.90

Graphical Abstract
  • -position of the pyrazine ring [10][11]. During small-scale late-stage functionalisation of natural products, we have observed that amination or amidation with primary amines often involves less of a kinetic barrier than might otherwise be expected [12][13][14]. The use of readily available liquid amines in
PDF
Album
Supp Info
Full Research Paper
Published 10 Jun 2025

Structure and thermal stability of phosphorus-iodonium ylids

  • Andrew Greener,
  • Stephen P. Argent,
  • Coby J. Clarke and
  • Miriam L. O’Duill

Beilstein J. Org. Chem. 2024, 20, 2931–2939, doi:10.3762/bjoc.20.245

Graphical Abstract
  • synthetic organic chemistry, becoming indispensable tools in total synthesis, late-stage functionalisation and radiolabelling [1][2][3][4][5][6][7][8][9]. Due to their great mechanistic flexibility, including reactivity as oxidants, electrophiles, radical precursors and transmetalating agents, they often
PDF
Album
Supp Info
Full Research Paper
Published 14 Nov 2024

Synthesis and characterisation of new antimalarial fluorinated triazolopyrazine compounds

  • Kah Yean Lum,
  • Jonathan M. White,
  • Daniel J. G. Johnson,
  • Vicky M. Avery and
  • Rohan A. Davis

Beilstein J. Org. Chem. 2023, 19, 107–114, doi:10.3762/bjoc.19.11

Graphical Abstract
  • , Australia Discovery Biology, Griffith University, Nathan, QLD 4111, Australia NatureBank, Griffith University, Nathan, QLD 4111, Australia 10.3762/bjoc.19.11 Abstract Nine new fluorinated analogues were synthesised by late-stage functionalisation using Diversinate™ chemistry on the Open Source Malaria (OSM
  • improve solubility and metabolic stability while retaining potency [5]. Late-stage functionalisation (LSF) is a strategy involving the use of C–H bonds as chemical handles for the introduction of various functional groups, which has been widely employed by medicinal chemists to generate new analogues of
PDF
Album
Supp Info
Full Research Paper
Published 31 Jan 2023

Applications of organocatalysed visible-light photoredox reactions for medicinal chemistry

  • Michael K. Bogdos,
  • Emmanuel Pinard and
  • John A. Murphy

Beilstein J. Org. Chem. 2018, 14, 2035–2064, doi:10.3762/bjoc.14.179

Graphical Abstract
  • mechanistic considerations are highlighted in the text when appropriate. Keywords: C–H functionalisation; heterocycles; late-stage functionalisation; medicinal chemistry; organic dyes; organic photocatalysts; peptide chemistry; photoredox catalysis; Review 1 Introduction 1.1 Main advantages of
  • are better suited to be included in the late stage functionalisation (LSF) section. 2.4 Reactions manipulating hydrocarbon backbones The reactions of hydrocarbons are central to building the scaffolds of molecules. This is also true in medicinal chemistry. There are countless C–C bond-forming
  • , milder conditions are employed and easily elaborated structures are accessed in one step. 4 Late stage functionalisation In this section, the bonds formed during the reactions are highlighted in red, as they are not always immediately and easily identifiable. Late stage functionalisation (LSF) is a
PDF
Album
Review
Published 03 Aug 2018
Other Beilstein-Institut Open Science Activities