Photoswitchable glycoligands targeting Pseudomonas aeruginosa LecA

• Yu Fan,
• Ahmed El Rhaz,
• Stéphane Maisonneuve,
• Emilie Gillon,
• Maha Fatthalla,
• Franck Le Bideau,
• Guillaume Laurent,
• Samir Messaoudi,
• Anne Imberty and
• Juan Xie

Beilstein J. Org. Chem. 2024, 20, 1486–1496, doi:10.3762/bjoc.20.132

• ; lectin A; photoswitchable ligands; Introduction Bacterial infection is a growing health problem due to antimicrobial resistance (AMR) among others. AMR causes approximately 33,000 deaths per annum in Europe only [1], and costs between €1.5 and €9 billion in healthcare and associated activities. Many

What contributes to an effective mannose recognition domain?

• Christoph P. Sager,
• Deniz Eriş,
• Martin Smieško,
• Rachel Hevey and
• Beat Ernst

Beilstein J. Org. Chem. 2017, 13, 2584–2595, doi:10.3762/bjoc.13.255

• lectin LecB [29][30] and Burkholderia cenocepacia with its characteristic B. cenocepacia lectin A (BC2L-A) [31][32], both playing an important role in the social life of bacterial cells. A further example is the bacterial adhesin FimH, which plays a crucial role in urinary tract infections (UTIs). FimH