Beilstein J. Org. Chem.2024,20, 2469–2475, doi:10.3762/bjoc.20.211
-shaped conformation it precipitates out of solution acting as a thermodynamic sink [5][6]. Shortly after, Cram et al. recognized the potential of resorcin[n]arenes as compounds large enough to encapsulate other simple molecules or ions and group them with other known macrocyclicarene compounds, e.g
reported herein may impact the synthesis of other macrocyclicarene species, e.g., calix[n]arenes, calix[4]pyrroles, pillar[n]arenes, and cucurbit[n]urils [90][91][92].
Perspective
Supramolecular chemistry is a mature field that has crossed boundaries into many other scientific areas. However, the work
Beilstein J. Org. Chem.2019,15, 1795–1804, doi:10.3762/bjoc.15.173
; macrocycles; macrocyclicarene; Introduction
Macrocyclic host molecules [1][2] play a significant role in host–guest chemistry. Compared with noncyclic molecules, the structures of macrocyclic hosts can greatly enhance the host–guest complexation ability through preorganization. Moreover, cyclic structures
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Graphical Abstract
Figure 1:
Structures and proton designations of hosts H1–5 and guests G1–4.