Beilstein J. Org. Chem.2024,20, 1922–1932, doi:10.3762/bjoc.20.168
; flow chemistry; Negishi; on-DNAchemistry; Introduction
DNA-encoded chemical library (DEL) technology is a powerful tool for hit identification [1][2]. DELs are chemically synthesized libraries in which every member is covalently attached to a unique DNA sequence serving as a molecular “barcode” [3
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Graphical Abstract
Scheme 1:
Known and improved synthetic strategies to access α-(hetero)aryl-amino acids.