N-Salicyl-amino acid derivatives with antiparasitic activity from Pseudomonas sp. UIAU-6B

• Joy E. Rajakulendran,
• Emmanuel Tope Oluwabusola,
• Michela Cerone,
• Terry K. Smith,
• Olusoji O. Adebisi,
• Adefolalu Adedotun,
• Gagan Preet,
• Sylvia Soldatou,
• Hai Deng,
• Rainer Ebel and
• Marcel Jaspars

Beilstein J. Org. Chem. 2025, 21, 1388–1396, doi:10.3762/bjoc.21.103

• remaining compounds showed activity at the highest concentrations tested. The plausible biosynthetic hypotheses toward the compounds were also proposed. Keywords: antiparasitic activity; biosynthesis pathway; phenolic siderophores; Pseudomonas species; pseudomonine; Introduction Species of the genus

• isolation of five phenolic siderophores with some of them exhibiting antimicrobial properties, including pseudomonins A–C and pseudomobactins A and B [15]. In this study we report the isolation and structural characterization of two previously undescribed as natural products (1 and 2) and two new compounds

• . for C7H5O3, 137.0244). A comparison of MS, 1D and 2D NMR data (see Supporting Information File 1, Figures S34–S36) of 7 with literature data of salicylic acid was consistent. Considering the structures of the previously undescribed phenolic siderophores (1–4), it is logical to assume that their

Amamistatins isolated from Nocardia altamirensis

• Till Steinmetz,
• Wolf Hiller and
• Markus Nett

Beilstein J. Org. Chem. 2022, 18, 360–367, doi:10.3762/bjoc.18.40

• Abstract Four new phenolic siderophores were isolated from the actinomycete Nocardia altamirensis along with the known natural product amamistatin B and a putative biosynthetic shunt product. The structures of all compounds were elucidated through 1D and 2D NMR analyses as well as mass spectrometry. The

Isolation and characterization of new phenolic siderophores with antimicrobial properties from Pseudomonas sp. UIAU-6B

• Emmanuel T. Oluwabusola,
• Olusoji O. Adebisi,
• Fernando Reyes,
• Kojo S. Acquah,
• Mercedes De La Cruz,
• Larry L. Mweetwa,
• Joy E. Rajakulendran,
• Digby F. Warner,
• Deng Hai,
• Rainer Ebel and
• Marcel Jaspars

Beilstein J. Org. Chem. 2021, 17, 2390–2398, doi:10.3762/bjoc.17.156

• Infectious Diseases Research in Africa, University of Cape Town, Rondebosch, 7701, South Africa 10.3762/bjoc.17.156 Abstract Five new phenolic siderophores 1–5 were isolated from the organic extract of a culture broth in a modified SGG medium of Pseudomonas sp. UIAU-6B, obtained from sediments collected

• 32 µg/mL. Compounds 2 and 3 exhibited moderate activity against Mycobacterium tuberculosis H37Rv, with MIC values of 7.8 and 15.6 µg/mL, respectively. Plausible biosynthetic hypotheses toward the new compounds 1–5 were proposed. Keywords: Mycobacterium tuberculosis; Phenolic siderophores

• microbial sources led to the isolation of Pseudomonas sp. UIAU-6B from sediments collected from the Oyun river in North Central Nigeria. Herein, we report the isolation and structure elucidation of seven secondary metabolites including five new (1–5), and two known phenolic siderophores (6 and 7) [28][36