Beilstein J. Org. Chem.2022,18, 1346–1354, doi:10.3762/bjoc.18.140
; imine; kinetics; pro-fragrance; Schiff base; Introduction
The fragrance and flavor industry is one of the most intensively developing sectors of the chemical industry. Encapsulation techniques are widely used in both food and cosmetic industries to control the delivery of the encapsulated guest
present an advantage compared to simple encapsulation and to other substrates as they will not only ensure very low volatility of the obtained pro-fragrance but also be able to encapsulate the guest after the cleavage of the covalent bond, leading to a two-in-one system. Indeed, encapsulation in CDs is
stability towards hydrolysis.
Kinetic studies of the imine hydrolysis by NMR
For the kinetic studies of the hydrolysis of imino-CDs, we selected the pro-fragrance 3d made from the most common aldehyde – benzaldehyde. The release of the benzaldehyde (2d) was studied by 1H NMR spectroscopy. Aqueous 0.1 M