Beilstein J. Org. Chem.2016,12, 1229–1235, doi:10.3762/bjoc.12.117
normal lymphocytes (IC50 = 230.8 µM).
Keywords: aminophosphonic derivatives; cytotoxicity; fluorescence properties; MTT test; pyrene-1-carboxaldehyde; Introduction
The biological activity of aminophosphonic systems is very well known and described, in aspect of their crop protective [1], antibacterial
properties.
This expectation is supported by the biological activity of azomethine derivatives of pyrene-1-carboxaldehyde. They show antimicrobial action, e.g., 1-phenytoinylacetic acid hydrazone of pyrene-1-carboxaldehyde demonstrated a moderate antimicrobial activity towards Escherichia coli and
Staphylococcus aureus [14]. Azomethine derivatives of pyrene-1-carboxaldehyde have shown enzyme inhibitory activity, as, e.g., its thiosemicarbazone, which is able to inhibit the action of urease [15].
Although fluorescence properties of pyrene-based aminophosphonic derivatives have been mentioned only once in a
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Graphical Abstract
Scheme 1:
Synthesis of aminophosphonates 3Aa–j, 3Ba–e, 3Ca–d, 3Cg, aminophosphonic acids 4a, 4c and hydroxyph...